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Updated: Feb 12, 2026

Imaging G Protein-coupled Receptor-mediated Chemotaxis and its Signaling Events in Neutrophil-like HL60 Cells
Published on: September 14, 2016
Two ways to move together: Force coordination in collective chemotaxis
Jessica L Pacheco1,2,3, Erica J Hutchins1,2,3
1Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA, USA.
Abstract:
Collective chemotaxis is often viewed through a mesenchymal lens, emphasizing peripheral polarity and force generation. In this issue, Diaz and Mayor (https://doi.org/10.1083/jcb.202507211) reveal that epithelial-like neural crest clusters achieve directed chemotaxis through a junction-centered strategy that redistributes polarity, contractility, and traction forces internally.
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