Related Experiment Video
Updated: Feb 12, 2026

Analyzing the Function of Small GTPases by Microinjection of Plasmids into Polarized Epithelial Cells
Published on: May 31, 2011
The curious incident of epithelial polarity where there should be none
Madeleine L Ball1, Katja Röper1,2
1Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Abstract:
In this issue, Almasoud et al. (https://doi.org/10.1083/jcb.202504139) report a surprising finding that epithelial cell polarity is present in a tissue with no known polarized function, in a cell type that was assumed to show a distinct lack of such polarity-the mesenchymal cells of the Drosophila fat body. Exceptions such as this help to broaden our understanding of the use of regulators and pathways we thought we fully understood.
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