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Follow the "DOTs": Vδ1+ γδ T cells as effectors of cancer immunotherapy

Bruno Silva-Santos1,2, Sofia Mensurado1, Rafael Blanco-Domínguez1

  • 1Gulbenkian Institute for Molecular Medicine , Lisbon, Portugal.

The Journal of Experimental Medicine
|February 11, 2026
PubMed

Cancer immunotherapy has mostly relied on conventional T cells to achieve success in a limited set of tumor types. A promising avenue to expand the repertoire of cancers effectively treated through immune intervention is to mobilize other anti-tumor effectors, such as γδ T cells. Among these, the Vδ1+ subset commonly predominates within peripheral tissues and within tumors, typically associating with good prognosis. In this Found in Translation, we discuss how to leverage the biological properties of Vδ1+ γδ T cells for cancer immunotherapy, with special focus on the delta one T (DOT) cell approach.

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