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Peripheral Perfusion Index: Normative Values from Electronically Reported CCHD Screening.

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This summary is machine-generated.

Peripheral perfusion index (PPI) may aid in identifying critical congenital heart disease (CCHD). This study established the first US reference ranges for neonatal PPI, finding it varies with gestational age and birth weight.

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Area of Science:

  • Neonatal physiology
  • Medical diagnostics
  • Public health screening

Background:

  • Peripheral perfusion index (PPI) quantifies pulsatile and non-pulsatile blood flow, potentially aiding critical congenital heart disease (CCHD) detection.
  • Existing reference ranges for neonatal PPI are limited, particularly in the United States.
  • Establishing normative PPI data is crucial for its integration into CCHD screening protocols.

Purpose of the Study:

  • To establish the first large, population-based reference ranges for peripheral perfusion index (PPI) in healthy neonates in the United States.
  • To evaluate the relationship between PPI and gestational age, birth weight, and sex in neonates.
  • To provide normative data for preductal and postductal PPI measurements at 24-48 hours of life.

Main Methods:

  • Retrospective observational study of 11,179 healthy neonates (35-41 weeks gestation) in Minnesota.
  • Evaluation of preductal and postductal PPI measured between 24 and 48 hours of life.
  • Utilized electronic CCHD screening data and GAMLSS R Package with a Sinh-Arcsinh distribution for percentile curve derivation.

Main Results:

  • Preductal PPI was significantly higher than postductal PPI.
  • PPI demonstrated a positive correlation with both gestational age and birth weight.
  • No significant difference in PPI was observed between sexes after adjusting for birth weight.

Conclusions:

  • This study provides the first comprehensive, population-based normative data for neonatal PPI in the United States.
  • The findings support previous international observations regarding PPI trends in relation to gestational age and birth weight.
  • Further research is warranted to assess the practical implementation and clinical utility of PPI in CCHD screening.