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Neuropsychological correlates of moyamoya disease: A clinical case study

Shelby B Hughes1, Anastasia Matchanova2, Lisa Delano-Wood2,3

  • 1San Diego State University/University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.

The Clinical Neuropsychologist
|February 11, 2026
PubMed
Abstract

Insights

Moyamoya disease (MMD) can cause significant cognitive decline, including language deficits, even after surgical revascularization. Early detection and intervention are crucial for optimizing outcomes in MMD patients.

Area of Science:

  • Neuroscience
  • Cerebrovascular Medicine
  • Neuropsychology

Background:

  • Moyamoya disease (MMD) is a rare, progressive cerebrovascular disorder.
  • It involves internal carotid artery stenosis and collateral vessel formation, leading to ischemic or hemorrhagic events.

Purpose of the Study:

  • To present a case study of a bilingual Filipina woman with MMD.
  • To detail her neuroimaging findings, surgical interventions, and post-operative neuropsychological outcomes.

Main Methods:

  • Neuroimaging confirmed Moyamoya disease (Suzuki grade III).
  • The patient underwent staged bilateral surgical revascularization (intracranial bypass and encephaloduroarteriosynangiosis).
  • A comprehensive neuropsychological battery was administered 18 months post-surgery.

Main Results:

  • The patient experienced an acute infarct following surgery.
  • Neuropsychological evaluation revealed global cognitive impairments (memory, executive function, processing speed, visuospatial abilities).
  • Severe language deficits were noted, including a language shift from English to Tagalog.

Conclusions:

  • This case highlights specific neuropsychological patterns in MMD.
  • Findings underscore the importance of early detection and timely surgical intervention for MMD.
  • Optimizing cognitive and functional outcomes in MMD requires prompt management.
Keywords:
Moyamoya diseaseaphasiacardiovascularclinical neuropsychologystroke

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