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Inherited cancer syndromes in adult oncology: a referral guide based on malignant tumor and polyp features
Audrey Guilmot1,2, Magali Belpaire3, Eric Olinger3
1Center for Human Genetics, Cliniques universitaires Saint-Luc, Brussels, Belgium. audrey.guilmot@chuv.ch.
Background:
Due to the challenges of identifying patients with hereditary cancer predispositions in oncology practice, we propose a comprehensive and practical tool intended for oncologists managing adult patients with malignant solid tumors and/or gastrointestinal polyps.
Methods:
This tool was developed based on a comprehensive review of international guidelines, GeneReviews, and recent literature. Key criteria for genetic referral were compiled and organized by organ site and tumor subtype.
Results:
The resulting resource includes a primary reference table for genetic referral, a polyposis-specific table, two visual summary figures and curated lists of associated genes and syndromes to streamline the clinical decision-making process.
Conclusions:
This comprehensive tool aims to support oncologists in the timely identification of patients eligible for genetic counseling, thereby enhancing therapeutic decisions and improving familial risk assessment.
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