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Urinary Oxygen Partial Pressure as a Potential Biomarker for Acute Kidney Injury: A Narrative Review
Jing Wen1,2,3, Kefan Duan1,2,3, Yuhang Ma1,2,3
1School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China.
Shock (Augusta, Ga.)
|February 11, 2026
Summary
Urinary oxygen partial pressure, a novel biomarker, can help predict acute kidney injury (AKI) in critically ill patients. Real-time, non-invasive detection methods offer potential for improved AKI prognosis and management.
Area of Science:
- Nephrology
- Critical Care Medicine
- Biomedical Engineering
Background:
- Acute kidney injury (AKI) is a significant complication in critically ill patients, often linked to renal ischemia.
- Reduced renal oxygenation is a key factor contributing to AKI development and progression.
- Current methods for assessing renal oxygenation can be invasive or lack real-time capabilities.
Purpose of the Study:
- To review the significance of urinary oxygen partial pressure as a potential biomarker for AKI.
- To explore novel non-invasive and real-time methods for detecting urinary oxygen.
- To evaluate the clinical utility of urinary oxygen partial pressure in predicting and managing AKI.
Main Methods:
- Literature review of studies investigating urinary oxygen partial pressure and AKI.
- Analysis of technological advancements in non-invasive urinary oxygen detection.
- Examination of existing data on the correlation between urinary oxygen levels and AKI outcomes.
Main Results:
- Urinary oxygen partial pressure reflects renal medullary oxygenation, offering insights into renal ischemia.
- Novel technologies enable real-time, non-invasive measurement of urinary oxygen.
- Preliminary evidence suggests urinary oxygen partial pressure's potential as a predictive and prognostic biomarker for AKI.
Conclusions:
- Urinary oxygen partial pressure is a promising, non-invasive biomarker for AKI.
- Real-time monitoring of urinary oxygen could enhance early AKI detection and risk stratification.
- Further clinical validation is warranted to establish the role of urinary oxygen partial pressure in AKI management.
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