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Integrative Assessment of the Diagnostic Significance of the microRNA (-21, -29a, -133a) Panel in Patients With

E I Tashina1, E V Privalova1, V Yu Kaplunova1

  • 1Sechenov First Moscow State Medical University, Moscow.

Kardiologiia
|February 11, 2026
PubMed
Abstract

Insights

A panel of microRNAs (miRNAs) can help diagnose hypertrophic cardiomyopathy (HCM). Specific miRNA levels, including increased microRNA-21 and decreased microRNA-29a, show diagnostic potential for HCM.

Area of Science:

  • Cardiovascular Research
  • Molecular Biology
  • Biomarker Discovery

Background:

  • Hypertrophic cardiomyopathy (HCM) is a primary genetic heart disease.
  • Accurate diagnosis and risk stratification are crucial for managing HCM.
  • Novel diagnostic markers are needed to improve early detection and patient outcomes.

Purpose of the Study:

  • To investigate the diagnostic value of circulating microRNA panel (-21, -29a, -133a) in patients with HCM.
  • To compare microRNA expression levels between HCM patients and a control group with arterial hypertension.
  • To assess the potential of these microRNAs as auxiliary diagnostic markers for HCM.

Main Methods:

  • A comparative study included 40 patients with confirmed HCM and 40 age- and sex-matched controls.
  • Comprehensive cardiac assessments included ECG, echocardiography, and Holter monitoring.
  • Plasma levels of microRNAs -21, -29a, and -133a were quantified using real-time PCR.

Main Results:

  • Significant differences in microRNA expression were observed between HCM patients and controls.
  • MicroRNA-21 was significantly increased (p<0.001), while microRNA-29a (p<0.001) and microRNA-133a (p<0.001) were significantly decreased in HCM patients.
  • Receiver Operating Characteristic (ROC) analysis showed high diagnostic accuracy for microRNA-21 (AUC=0.887) and microRNA-29a (AUC=0.884).

Conclusions:

  • The microRNA panel (-21, -29a, -133a) demonstrates significant diagnostic potential for HCM.
  • Elevated microRNA-21 and reduced microRNA-29a correlate with myocardial fibrosis.
  • Suppressed microRNA-133a indicates hypertrophic remodeling, suggesting these miRNAs as promising auxiliary markers for HCM.

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