Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Histone Variants at the Centromere02:30

Histone Variants at the Centromere

5.1K
Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3...
5.1K
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

7.6K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
7.6K
Integration by Parts: Indefinite Integrals01:26

Integration by Parts: Indefinite Integrals

230
Integration by parts is a fundamental technique in calculus for evaluating integrals involving the product of two functions. It is particularly useful when direct integration is not feasible. The method is based on the product rule for differentiation, which states that the derivative of a product equals the derivative of the first function times the second, plus the first function times the derivative of the second. By integrating this identity and rearranging terms, the integration by parts...
230
Integration by Parts: Definite Integrals01:23

Integration by Parts: Definite Integrals

92
Definite integrals involving the product of two functions over a fixed interval can be evaluated using integration by parts. This method rewrites the integral as the difference of a product evaluated at the endpoints and a remaining definite integral that is often simpler to compute.A representative example is the definite integral of the inverse tangent function. Since there is no direct integration formula for arctan ⁡x, the integrand is rewritten as a product of arctan⁡ x and the...
92
Computed Tomography01:10

Computed Tomography

8.9K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
8.9K
Dynamic Equilibrium02:20

Dynamic Equilibrium

63.4K
A reversible chemical reaction represents a chemical process that proceeds in both forward (left to right) and reverse (right to left) directions. When the rates of the forward and reverse reactions are equal, the concentrations of the reactant and product species remain constant over time and the system is at equilibrium. A special double arrow is used to emphasize the reversible nature of the reaction. The relative concentrations of reactants and products in equilibrium systems vary greatly;...
63.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Basit et al. Brassinosteroid Supplementation Alleviates Chromium Toxicity in Soybean (<i>Glycine max</i> L.) via Reducing Its Translocation. <i>Plants</i> 2022, <i>11</i>, 2292.

Plants (Basel, Switzerland)·2026
Same author

Successful Management of Severe Hypertriglyceridemia Presenting With Eruptive Xanthomas as an Outpatient Without Development of Acute Pancreatitis: A Case Report.

Cureus·2026
Same author

Anticancer potential of geranyl acetate through RelA gene downregulation in acute myeloid leukemia cells.

Scientific reports·2026
Same author

Population pharmacokinetics and resistance patterns of vancomycin and amikacin in pediatric oncology patients.

Drug metabolism and disposition: the biological fate of chemicals·2026
Same author

Volatile versus intravenous anesthesia and postoperative neurocognition: A meta-analysis and trial-sequential analysis.

Journal of clinical anesthesia·2026
Same author

Retraction notice to 'Hydrogeochemical properties, source provenance, distribution, and health risk of high fluoride groundwater: Geochemical control, and source apportionment' [Environ. Pollut. 362, (2024) 125000].

Environmental pollution (Barking, Essex : 1987)·2026

Related Experiment Video

Updated: Feb 13, 2026

Following the Dynamics of Structural Variants in Experimentally Evolved Populations
04:52

Following the Dynamics of Structural Variants in Experimentally Evolved Populations

Published on: February 3, 2023

1.4K

Pathogenic KRAS variants disrupt structure and dynamics: Insights from integrated computational analyses.

Saqib Ishaq1,2,3, Aizaz Ali4, Obaid Habib1

  • 1Guangdong Provincial Key Laboratory of System Biology and Synthetics Biology for Urogenital Tumors, School of Basic Medicine, Shenzhen University Medical School, Shenzhen University (SZU), Shenzhen, Guangdong, China.

Plos One
|February 11, 2026
PubMed
Summary

Computational analysis identified four detrimental KRAS gene variants (L79P, A130P, G138E, F141L) that destabilize protein structure, potentially driving oncogenic activation in cancers like colorectal and lung cancer.

More Related Videos

Incorporating Target Protein Structure Flexibility and Dynamics in Computational Drug Discovery Using Ensemble-Based Docking Analysis
08:49

Incorporating Target Protein Structure Flexibility and Dynamics in Computational Drug Discovery Using Ensemble-Based Docking Analysis

Published on: June 20, 2025

1.3K
Advanced Self-Healing Asphalt Reinforced by Graphene Structures: An Atomistic Insight
08:03

Advanced Self-Healing Asphalt Reinforced by Graphene Structures: An Atomistic Insight

Published on: May 31, 2022

5.7K

Related Experiment Videos

Last Updated: Feb 13, 2026

Following the Dynamics of Structural Variants in Experimentally Evolved Populations
04:52

Following the Dynamics of Structural Variants in Experimentally Evolved Populations

Published on: February 3, 2023

1.4K
Incorporating Target Protein Structure Flexibility and Dynamics in Computational Drug Discovery Using Ensemble-Based Docking Analysis
08:49

Incorporating Target Protein Structure Flexibility and Dynamics in Computational Drug Discovery Using Ensemble-Based Docking Analysis

Published on: June 20, 2025

1.3K
Advanced Self-Healing Asphalt Reinforced by Graphene Structures: An Atomistic Insight
08:03

Advanced Self-Healing Asphalt Reinforced by Graphene Structures: An Atomistic Insight

Published on: May 31, 2022

5.7K

Area of Science:

  • Oncogenomics
  • Computational Biology
  • Structural Biology

Background:

  • KRAS is a frequently mutated oncogene in pancreatic, colorectal, and lung cancers.
  • Mechanisms by which KRAS variants alter function are poorly understood.
  • This study focuses on identifying detrimental non-synonymous single nucleotide polymorphisms (nsSNPs) in KRAS.

Purpose of the Study:

  • Identify and characterize pathogenic KRAS nsSNPs.
  • Elucidate atomistic effects of these variants on KRAS structure, stability, and oncogenic potential.

Main Methods:

  • Screened 173 nsSNPs using an integrated computational workflow.
  • Employed pathogenicity prediction, evolutionary conservation, structural modeling, molecular docking, and molecular dynamics simulations.
  • Assessed post-translational modifications and protein-protein interactions.

Main Results:

  • Identified four high-impact deleterious variants: L79P, A130P, G138E, and F141L.
  • Simulations showed these variants perturb conformational stability, residue flexibility, and binding energetics.
  • Variants are linked to colorectal, pancreatic, and lung cancers, indicating clinical relevance.

Conclusions:

  • Provides mechanistic insights into KRAS variations driving oncogenic activation.
  • Identified variants are high-priority targets for experimental validation.
  • Highlights the utility of computational methods in cancer biology research.