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The process of converting very light nuclei into heavier nuclei is also accompanied by the conversion of mass into large amounts of energy, a process called fusion. The principal source of energy in the sun is a net fusion reaction in which four hydrogen nuclei fuse and ultimately produce one helium nucleus and two positrons.
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Related Experiment Video

Updated: Feb 13, 2026

Analysis of SNARE-mediated Membrane Fusion Using an Enzymatic Cell Fusion Assay
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An Adolescent Sacroiliac Spindle Cell Tumor With PDGFB Fusion.

Yaling Jiang1, Nong Lin1, Zhaoming Ye1

  • 1Department of Orthopaedics, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

Journal of the National Comprehensive Cancer Network : JNCCN
|February 11, 2026
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Summary

A rare, aggressive sacroiliac spindle cell tumor in a teen was identified via RNA sequencing as having a COL1A1::PDGFB fusion, characteristic of dermatofibrosarcoma protuberans (DFSP). Targeted therapy showed efficacy, expanding DFSP understanding.

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Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations
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Area of Science:

  • Oncology
  • Molecular Pathology
  • Surgical Pathology

Background:

  • Spindle cell neoplasms in the sacroiliac region present diagnostic and therapeutic challenges.
  • Dermatofibrosarcoma protuberans (DFSP) is typically superficial but can present atypically.

Purpose of the Study:

  • To report a rare case of an aggressive sacroiliac spindle cell neoplasm.
  • To highlight the diagnostic utility of molecular studies (RNA sequencing) in challenging cases.
  • To discuss the therapeutic implications of identifying a COL1A1::PDGFB fusion.

Main Methods:

  • Diagnostic imaging and laboratory tests for tumor localization.
  • Surgical excision and curettage for tumor removal.
  • RNA sequencing to identify specific genetic fusions (COL1A1::PDGFB).
  • Treatment with imatinib mesylate and radiotherapy for recurrent disease.

Main Results:

  • A 16-year-old male presented with a sacroiliac tumor causing neurological symptoms.
  • RNA sequencing identified the COL1A1::PDGFB fusion, characteristic of DFSP.
  • The tumor exhibited aggressive clinical behavior, including recurrence and metastasis.
  • The patient achieved a sustained partial response to imatinib mesylate and radiotherapy.

Conclusions:

  • The COL1A1::PDGFB fusion may indicate an aggressive variant of DFSP, even in deep-seated locations.
  • Molecular diagnostics are crucial for accurate classification of challenging spindle cell neoplasms.
  • Targeted therapies like imatinib mesylate show promise in managing aggressive DFSP variants.