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Doping cDC1s for tolerance
Victor Bosteels1, Sophie Janssens2
1Immunobiology Laboratory, Francis Crick Institute, London, UK.
Type 1 conventional dendritic cells (cDC1s) are key antigen-presenting cells and have been implicated in the induction of peripheral tolerance, yet how cDC1s actively enforce immune tolerance remains unclear. In a recent issue of Nature, Zhang et al. propose that erythropoietin receptor signaling biases cDC1s toward a maturation state associated with immune tolerance across transplantation, homeostasis, and cancer.
Type 1 conventional dendritic cells (cDC1s) are key antigen-presenting cells and have been implicated in the induction of peripheral tolerance, yet how cDC1s actively enforce immune tolerance remains unclear. In a recent issue of Nature, Zhang et al. propose that erythropoietin receptor signaling biases cDC1s toward a maturation state associated with immune tolerance across transplantation, homeostasis, and cancer.
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