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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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Histone Modification02:32

Histone Modification

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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
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siRNA - Small Interfering RNAs02:30

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Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
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Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

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Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
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piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

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PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
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Related Experiment Video

Updated: Feb 13, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

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Rising Star: Combining Bioinformatics and Experimental Biology to Decoding Non-coding RNAs and RNA Modifications.

Xiu-Jie Wang1

  • 1Center for Zero-to-One Innovation, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, China.

Journal of Molecular Biology
|February 11, 2026
PubMed
Summary
This summary is machine-generated.

Researchers identified microRNAs regulating m6A RNA modification, impacting plant, viral, and stem cell processes. This discovery extends to understanding long-term memory formation and developing bioinformatics tools.

Keywords:
bioinformaticsm(6)A RNA modificationmicroRNAsnon-coding RNAs

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Area of Science:

  • Bioinformatics
  • Molecular Biology
  • Genetics

Background:

  • Xiu-Jie Wang's research group focuses on identifying functional non-coding RNAs, particularly microRNAs.
  • Utilizes a combination of bioinformatics and experimental methods to study RNA regulation.
  • Previous work has explored microRNAs in plants, viruses, and mouse embryonic stem cells.

Purpose of the Study:

  • To identify functional non-coding RNAs and their roles in biological processes.
  • To investigate the novel function of microRNAs in regulating m6A RNA modification.
  • To explore the role of m6A regulation in long-term memory formation.

Main Methods:

  • Bioinformatic analysis of non-coding RNAs.
  • Experimental validation of microRNA functions.
  • Development of bioinformatics tools and databases.

Main Results:

  • Identified numerous microRNAs involved in essential physiological processes.
  • Discovered a novel function of microRNAs in regulating m6A RNA modification.
  • Extended research into m6A regulation and its connection to long-term memory.

Conclusions:

  • MicroRNAs play a significant role in regulating m6A RNA modification.
  • Findings provide insights into the molecular mechanisms of long-term memory.
  • Developed valuable bioinformatics resources for the scientific community.