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Updated: Feb 13, 2026

The C-seal: A Biofragmentable Drain Protecting the Stapled Colorectal Anastomosis from Leakage
Published on: November 4, 2010
Comment on: Three Versus Two-Rows Circular Stapler in Colorectal Anastomosis: Short Term Outcomes
Jeremy Meyer1,2
1Division of Digestive Surgery, University Hospitals of Geneva, Genève, Switzerland.
None:
This letter comments on a recent study comparing two-row and three-row circular staplers in colorectal cancer surgery. We highlight methodological limitations related to the use of historical controls, evolving perioperative practices, and limited event numbers, which may confound the observed reduction in anastomotic leakage. Current evidence does not conclusively support the superiority of triple-row staplers, underscoring the need for prospective studies using standardized modern protocols.
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