Atypical Cogan's Syndrome Is Common among Japanese Patients: A Case Report and Literature Review in Japan
Takao Nagashima1, Toshikatsu Kaburaki2,3
1Division of Rheumatology, Department of Medicine, Jichi Medical University Saitama Medical Center, Japan.
Abstract:
We report the case of a 55-year-old Japanese woman who presented with fever, headache, vertigo, sensorineural hearing loss, and scleritis, leading to a diagnosis of Cogan's syndrome (CS). Her hearing acuity recovered to previous levels after high-dose glucocorticoid treatment, despite seven weeks having passed since the onset. We reviewed 30 adult cases of Japanese CS using PubMed and Ichushi-Web. We identified several clinical features of Japanese patients with CS, including an older age of onset, less interstitial keratitis, more frequent fever and headache, elevated inflammatory marker levels, and a higher prevalence of large-vessel vasculitis, compared with studies on Caucasians.
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