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Updated: Feb 13, 2026

Two-Dimensional Super-Resolution Visualization of Rat Brain Microvasculature Using Ultrasound Localization Microscopy
Published on: March 28, 2025
[Research and Application of Super-Resolution Ultrasound Microvascular Imaging Technique]
Yigang Du1, Maodong Sang1, Zhilan Zheng1
1Shenzhen Mindray Bio-Medical Electronics Co., Ltd., Shenzhen, 518057.
Abstract:
This paper elaborates on the research progress of super-resolution ultrasound imaging technique, detailing each step involved in the implementation process of this technology (ultrasound transmission and scanning, beamforming, clutter filtering, microbubble localization and tracking, etc.), and summarizes existing problems and potential solutions based on existing literature. Targeting relevant clinical applications and demand scenarios, the paper focuses on four future directions of super-resolution imaging technology, including 3D super-resolution imaging, realization of productization, contrast-free super-resolution, and artificial intelligence (AI) technology. In addition, the paper introduces the calculation methods of multiple quantitative parameters based on the function of super-resolution imaging, and demonstrates the calculation results and correlations of different parameters (fractal dimension, directional entropy, and circular variance) through simulations.
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