Related Experiment Video

Updated: Feb 13, 2026

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock
06:10

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

Published on: June 12, 2021

3.7K

Bleeding in Patients With Infarct-Related Cardiogenic Shock: A DanGer Shock Substudy

Rikke Sørensen1, Jacob Eifer Møller2, Christophe Vandenbriele3

  • 1Department of Cardiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

JACC. Cardiovascular Interventions
|February 11, 2026
PubMed

Insights

The microaxial flow pump (mAFP) increased bleeding events in ST-elevation myocardial infarction and cardiogenic shock patients compared to standard care. Bleeding risk also rose with mechanical circulatory support complexity, with half occurring post-removal.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Mechanical Circulatory Support

Background:

  • Microaxial flow pump (mAFP) shows promise for ST-elevation acute myocardial infarction with cardiogenic shock (STEMI-CS).
  • mAFP use is linked to increased bleeding events, necessitating further investigation.

Purpose of the Study:

  • To analyze bleeding events in STEMI-CS patients treated with mAFP versus standard care.
  • To assess the relationship between bleeding and mechanical circulatory support (MCS) complexity.

Main Methods:

  • The DanGer Shock trial randomized 355 STEMI-CS patients to mAFP or standard care.
  • Bleeding was categorized using Bleeding Academic Research Consortium (BARC) types 3-5.
  • Follow-up included assessment of bleeding during and after MCS use.

Main Results:

  • mAFP group had significantly higher BARC 3-5 bleeding (26.3%) than standard care (15.3%) (P < 0.001).
  • Bleeding risk increased with MCS complexity: mAFP (OR 4.94), VA-ECMO (OR 8.06), and combined mAFP+VA-ECMO (OR 27.40).
  • Multivariable analysis identified mAFP use, renal replacement therapy, and VA-ECMO escalation as bleeding predictors.

Conclusions:

  • Patients receiving mAFP experienced more severe bleeding than those on standard care.
  • Bleeding events were associated with MCS complexity and frequently occurred after device removal.
Abstract

Keywords:
STEMIbleedingcardiogenic shockmicroaxial-flow-pump

More Related Videos

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock07:39

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock

Published on: August 16, 2021

4.2K
Drosophila Adult Olfactory Shock Learning09:48

Drosophila Adult Olfactory Shock Learning

Published on: August 7, 2014

29.2K

Related Concept Videos

Shock Waves01:16

Shock Waves

While deriving the Doppler formula for the observed frequency of a sound wave, it is assumed that the speed of sound in the medium is greater than the source's speed through it. When this condition is breached, a shock wave occurs.
When the source's speed approaches the speed of sound, constructive interference between successive wavefronts emitted by the source occurs immediately behind it. Initially, scientists believed that this constructive interference would result in such high...
2.6K
Blood Pressure Imbalances and Circulatory Shock01:24

Blood Pressure Imbalances and Circulatory Shock

Disorders affecting blood volume, vascular tone, or vascular function can disrupt vascular homeostasis, including conditions like hypertension, hemorrhage, and shock.
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
1.7K
Bleeding in Fresh Concrete01:22

Bleeding in Fresh Concrete

Bleeding in fresh concrete occurs when water from the mix rises to the surface. This happens because the mix's solid components fail to retain all the water as they settle, leading to separation where water collects at the top. The severity of bleeding can be measured by assessing the total settlement or by noting the decrease in height per unit height of concrete.
Bleeding can cause several issues in the concrete structure. Sometimes, the rising water gets trapped beneath large aggregate...
616
Patient-centered Care01:13

Patient-centered Care

Patient-centered care involves delivering care beyond inpatient hospitalization. Reflective practice can enhance a patient-centered approach. Reflective practice is a process of reasoning that considers all aspects of the present situation, including practicalities, learning from personal practice, and consideration of patient needs. Patients appreciate care decisions made while considering their input. Involving the patient in their care provides the patient with a sense of contribution rather...
3.1K
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
278
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
269