Related Experiment Video
Updated: Feb 13, 2026

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
Published on: July 24, 2013
Preoperative frailty prevalence and risk factors in oral cancer patients: a meta-analysis
Huipin Wang1, Jianhuan Che2, Ye Zhang2
1School of Nursing, Jilin University, No.965 Xinjiang Street, Changchun 130021, Jilin, China.
Abstract:
To determine the prevalence of preoperative frailty among oral cancer patients and identify its risk factors, a thorough review of observational studies published until 30 August 2025 was performed in various databases, including PubMed, Web of Science, Cochrane Library, Embase, CINAHL, CNKI, CBM, and Wanfang. The primary outcome was the prevalence of preoperative frailty or associated factors. Risk of bias and methodological quality were independently evaluated by two authors using both the Newcastle-Ottawa Scale (NOS) and Agency for Healthcare Research and Quality (AHRQ) criteria. The meta-analysis included 18 articles. The results indicated that the prevalence of preoperative frailty in oral cancer patients was 42.2%. The risk factors included age, cognitive impairment, American Society of Anesthesiologists' (ASA) score of ≥3, more than five medications, Charlson comorbidity index (CCI) score of ≥2, and a low skeletal muscle index (SMI). Body mass index (BMI) was identified as a protective factor. The findings can enable healthcare providers to implement effective interventions to prevent, reverse, or delay the progression of frailty.
Related Concept Videos
Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
Drug Toxicity: Risk factors
Prevalence and Incidence
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
Factors Affecting Protein-Drug Binding: Patient-Related Factors
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
Cancer Survival Analysis
Directing Effect of Substituents: meta-Directing Groups

