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Updated: Feb 13, 2026
A Nonsequencing Approach for the Rapid Detection of RNA Editing
Published on: April 21, 2022
RNA editing in cardiovascular health and disease
Xiaoxin Huang1, Charles Solomon2, David G McVey2,3
1Division of Basic Medicine, Shantou University Medical College, Shantou, China.
None:
Post-transcriptional RNA modifications can alter RNA structure, stability, localization, and function. Adenosine-to-inosine (A-to-I) RNA editing is a post-transcriptional modification that converts adenosine nucleotides in RNA to inosine nucleotides, catalyzed by adenosine-deaminase-acting-on-RNA (ADAR) enzymes. Recent studies have shown that A-to-I RNA editing is required for cardiovascular development and homeostasis whilst aberrant RNA editing plays a role in cardiovascular diseases. This article provides an overview of A-to-I RNA editing events that have been implicated in cardiovascular biology and disease. It also discusses harnessing RNA editing for cardiovascular disease biomarker development and engineering RNA editing for cardiovascular disease treatment.
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