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Related Experiment Video

Updated: Feb 13, 2026

Investigating the Neural Mechanisms of Aware and Unaware Fear Memory with fMRI
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Astrocytes enable amygdala neural representations supporting memory.

Olena Bukalo1, Ruairi O'Sullivan2, Yuta Tanisumi3

  • 1Laboratory of Behavioral and Genomic Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA. Olena.Bukalo@nih.gov.

Nature
|February 11, 2026
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Summary
This summary is machine-generated.

Astrocytes in the basolateral amygdala (BLA) dynamically track fear states and aid in fear memory retrieval and extinction. This research highlights the crucial role of these non-neuronal cells in adaptive fear responses.

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Related Experiment Videos

Last Updated: Feb 13, 2026

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Area of Science:

  • Neuroscience
  • Cell Biology

Background:

  • Fear memory and extinction involve neural circuits in the basolateral amygdala (BLA).
  • The role of non-neuronal cells, specifically astrocytes, in these processes is not well understood.

Purpose of the Study:

  • To investigate the contribution of BLA astrocytes to fear memory and extinction.
  • To elucidate the mechanisms by which astrocytes influence neuronal activity during fear recall and extinction.

Main Methods:

  • In vivo calcium imaging of BLA astrocytes and neurons.
  • Causal manipulation of astrocyte activity in awake, behaving mice.
  • Electrophysiological recordings in the BLA-prefrontal circuit.

Main Results:

  • BLA astrocytes dynamically track the animal's fear state.
  • Astrocyte activity is essential for fear memory retrieval and extinction.
  • Astrocyte calcium signaling facilitates neuronal encoding and readout of fear memory through the BLA-prefrontal pathway.

Conclusions:

  • Astrocytes play a critical role in generating and adapting neural representations of fear states.
  • These findings challenge neurocentric models by revealing a significant function for astrocytes in amygdala-mediated adaptive behaviors.
  • Astrocytes are integral components of fear memory and extinction circuits.