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Disodium cromoglycate in anaphylaxis and pollinois
Annals of Allergy
|March 1, 1978
Summary
Disodium cromoglycate (DSCG) did not prevent anaphylaxis in rabbits. However, DSCG effectively inhibited hay fever symptoms in humans by preserving mast cell integrity.
Area of Science:
- Pharmacology
- Immunology
- Cell Biology
Background:
- Disodium cromoglycate (DSCG) is used to treat allergic conditions.
- The precise mechanism of action for DSCG remains unclear.
- Understanding DSCG's effects on mast cells is crucial for allergy treatment.
Purpose of the Study:
- To investigate the mode of action of disodium cromoglycate.
- To elucidate DSCG's effects on mast cells during allergic reactions.
- To evaluate DSCG's efficacy in both passive anaphylaxis and allergic rhinitis models.
Main Methods:
- Morphological experiments using rabbit ear chambers during induced anaphylaxis.
- Histological examination of mast cells and their granules post-anaphylaxis.
- Exposure of human nasal mucosa to ragweed pollen, with and without DSCG pre-treatment.
Main Results:
- DSCG did not prevent gross or microscopic changes in rabbits during anaphylaxis.
- DSCG failed to protect mast cells in rabbits experiencing passive anaphylaxis.
- DSCG pre-treatment of human nasal mucosa prevented hay fever symptoms and reduced mast cell degranulation.
Conclusions:
- DSCG's efficacy in treating allergic rhinitis may stem from its action on human mast cells in the nasal mucosa.
- DSCG's mechanism of action appears to differ between systemic anaphylaxis models and topical application for allergic rhinitis.
- Further research is warranted to fully understand DSCG's therapeutic effects and target specific allergic pathways.