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In order to make good decisions, we use our knowledge and our reasoning. Often, this knowledge and reasoning is sound and solid. However, sometimes, we are swayed by biases or by others manipulating a situation. For example, let’s say you and three friends wanted to rent a house and had a combined target budget of $1,600. The realtor shows you only very run-down houses for $1,600 and then shows you a very nice house for $2,000. Might you ask each person to pay more in rent to get the...
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In the plasma membrane, the lipids forming the bilayer can also act as an anchor to tether proteins to the membrane. The three main types of lipid anchors found in eukaryotes are – prenyl groups, fatty acyl groups, and glycosylphosphatidylinositol or GPI groups. Prenyl and fatty acyl groups act as anchors on the cytosolic surface of the membrane, whereas GPI anchors proteins on the extracellular side.
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GPI-anchoring is a post-translational, reversible protein modification that is ubiquitous in eukaryotes. Such proteins are primarily present on the exoplasmic leaflet of the plasma membrane.
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Tail-anchored, or TA, proteins are estimated to make up to 3-5% of membrane proteins found in the eukaryotic cell. Such proteins have a single transmembrane domain located approximately 30 amino acid residues upstream from the C-terminal end. As a result, the signal recognition particle (SRP) cannot guide a TA protein to the ER membrane for cotranslational insertion. Hence, they are integrated into the ER membrane post-translationally using their C-terminal end as the anchor. TA proteins...
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Updated: Feb 13, 2026

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Microneedle Stent for Intravascular Anchoring Effect.

GeonA Kim1, Dong-Sung Won2, Dong-Su Kim3

  • 1Department of Mechanical Engineering, Incheon National University, Incheon, Republic of Korea.

Advanced Healthcare Materials
|February 11, 2026
PubMed
Summary
This summary is machine-generated.

This study introduces a novel microneedle stent (MNS) to enhance vascular stent anchoring and stability. Microneedles improve stent fixation, potentially reducing complications and improving outcomes for cardiovascular disease patients.

Keywords:
3d printed PCL stentanchoring effectconformal transfer moldingmicroneedlestent dislodgement

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Cardiovascular Research

Background:

  • Cardiovascular diseases are a leading cause of death, often treated with stents.
  • Current stents face complications like migration and dislodgement.
  • Improved stent anchoring is crucial for better clinical outcomes.

Purpose of the Study:

  • To develop and evaluate a novel microneedle stent (MNS) for enhanced vascular fixation.
  • To explore the potential of microneedles for improving stent stability and reducing complications.

Main Methods:

  • Microneedle arrays were integrated onto 3D-printed polycaprolactone stents using UV-curable resin transfer-molding.
  • Microneedle structural fidelity, mechanical strength, and adhesion were characterized.
  • In vitro flow studies and in vivo implantation were performed to assess anchoring and biocompatibility.

Main Results:

  • The MNS demonstrated high structural fidelity and tunable mechanical properties.
  • UV-crosslinking conditions controlled microneedle adhesion to the stent.
  • In vitro and in vivo studies confirmed robust vascular fixation without adverse inflammatory responses.

Conclusions:

  • This work presents the first integration of microneedles into vascular stents.
  • The novel MNS offers a promising strategy to enhance stent stability and clinical outcomes.
  • Microneedle technology holds potential for improving cardiovascular interventions.