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Factors Influencing Attraction I: Proximity01:22

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Proximity plays a fundamental role in shaping interpersonal attraction by increasing opportunities for interaction and fostering familiarity. Research consistently demonstrates that individuals are more likely to form social bonds with those who are physically closer to them, whether in residential settings, workplaces, or educational institutions. This effect is largely driven by the increased frequency of encounters, which facilitates the development of friendships and romantic...
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An emf is induced when the magnetic field in a coil is changed by pushing a bar magnet into or out of the coil. emfs of opposite signs are produced by motion in opposite directions, and the directions of emfs are also reversed by reversing poles. The same results are produced if the coil is moved rather than the magnet—it is the relative motion that is important. The faster the motion, the greater the emf. Additionally, there is no emf when the magnet is stationary relative to the coil.
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Inductance is the property of a device that tells us how effectively it induces an emf in another device. In other words, it is a physical quantity that expresses the effectiveness of a given device.
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Creating Avian Forebrain Chimeras to Assess Facial Development
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Lysine Targeting Group-Transfer Chimeras for Proximity Induction.

Sameek Singh1, Kien Tran1,2, Endri Karaj1

  • 1Chemical Biology and Therapeutics Science, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.

Angewandte Chemie (International Ed. in English)
|February 12, 2026
PubMed
Summary
This summary is machine-generated.

Researchers created group-transfer chimeras (GRCs) to modify proteins. These GRCs link cancer cells to T cells, activating an immune response against cancer.

Keywords:
Group transferImmunotherapyLysineProtein modificationsProteomics

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Immunology

Background:

  • Post-translational modifications (PTMs) are key to protein interactions.
  • Proteins often have lysine residues near their ligands, suggesting a modification site.

Purpose of the Study:

  • To develop a novel method for protein modification and proximity induction.
  • To create a platform for targeted cancer cell engagement and immunotherapy.

Main Methods:

  • Developed group-transfer chimeras (GRCs) utilizing protein ligands and a novel SuFA handle.
  • Engineered GRCs to transfer protein binders (e.g., HaloTag, FKBP) to lysine residues on cancer cells.
  • Utilized a universal T cell engager (UniTE) to link modified cancer cells with T cells.

Main Results:

  • The SuFA handle demonstrated stability, small size, and tunable reactivity, overcoming limitations of previous methods.
  • GRCs successfully displayed protein binders on the surface of cancer cells.
  • The GRC-UniTE system induced proximity between cancer cells and cytotoxic T cells, leading to T cell activation.

Conclusions:

  • GRCs represent a versatile platform for protein engineering and targeted biological applications.
  • This technology holds promise for basic research and the development of novel cancer immunotherapies.