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Updated: Feb 13, 2026

A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis
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A Mouse Model for Vascular Cognitive Impairment and Dementia Based on Needle-guided Asymmetric Bilateral Common Carotid Artery Stenosis

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Intermittent hypoxic perconditioning improves cognitive function in a mouse model of vascular cognitive impairment

Feiyang Jin1,2, Zhengming Tian1, Yuying Guan1

  • 1Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Laboratory for Hypoxia Adaptation Translational Medicine, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Capital Medical University, Beijing, China.

Neural Regeneration Research
|February 12, 2026
PubMed

Keywords:
bilateral carotid artery stenosiscerebrovascular microcirculationchronic cerebral hypoperfusioncognitive functionhigh fat-high fructose diethippocampusintermittent hypoxiamitochondrial respiratory chainprefrontal cortexvascular cognitive impairment and dementia

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