Related Experiment Video
Updated: Feb 13, 2026

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes
Published on: February 17, 2023
Subcutaneous Catheter Type and Wear Duration in Automated Insulin Delivery Systems: Associations with Glycemic
Alexia Aouba1, Bleuenn Dreves1, Julia Morera1
1Department of Endocrinology and Diabetology, Caen University Hospital, Caen-Normandy, France.
Introduction:
Automated insulin delivery (AID) systems represent a major advancement in the management of type 1 diabetes (T1D). While their metabolic efficacy is well established, limited data are available on the impact of catheter type and/or wear duration on glycemic outcomes. This study aimed to evaluate these parameters in real-life conditions.
Methods:
We conducted a single-center, retrospective, observational study including 321 adults with T1D using an AID system. Analyses focusing on infusion set characteristics were restricted to the 279 patients using tubed pumps. Clinical and glycemic data were extracted from medical records and device software (pumps and sensors). The main parameters assessed were catheter type (perpendicular or angled), cannula length, wear duration, and continuous glucose monitoring (CGM) derived glycemic outcomes.
Results:
The cohort included 321 patients (51% female), with a mean age of 48 ± 15.1 years, diabetes duration of 25 ± 13.3 years, and a mean body mass index (BMI) of 27 ± 4.9 kg/m2. The mean time in range was 70% ± 16.2, time below range 2% ± 2.5, and coefficient of variation 34% ± 7.1. Comparisons between perpendicular (88.9%) and angled catheters (11.1%), as well as between different cannula lengths, showed no significant differences in glycemic outcomes. The mean wear duration was 4.6 ± 2.0 days, longer than recommended, but not associated with poorer glycemic control. Conversely, wear duration was inversely correlated with body weight, BMI, and total daily insulin dose, particularly for perpendicular catheters.
Conclusion:
Infusion set type, cannula length, and wear duration were not significantly associated with glycemic outcomes among patients using tubed pumps in real-life AID use. Wear duration was associated with anthropometric parameters and insulin requirements.
Related Concept Videos
Insulin Formulations: Types and Delivery
Short-acting insulins are divided into...
Drug Delivery Systems: Different Types
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Diabetes Mellitus: Type 2 and Gestational
Types of Hormones
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...

