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Related Concept Videos

Nucleic Acids02:43

Nucleic Acids

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
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Nucleic acids02:43

Nucleic acids

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
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The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
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Nucleic Acids02:43

Nucleic Acids

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Nucleic Acid Structure01:25

Nucleic Acid Structure

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The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
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Nucleic Acids and Nucleotides01:20

Nucleic Acids and Nucleotides

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and have instructions for its functioning. The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA).
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Biosynthesis of Nucleic Acids01:28

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Nucleic acid biosynthesis is a fundamental biochemical process that produces the purine and pyrimidine nucleotides essential for DNA and RNA synthesis. This pathway maintains a balanced nucleotide pool, preventing imbalances that could jeopardize genetic integrity and cellular function. Given the crucial role of nucleotides, their synthesis is tightly regulated to ensure proper cellular homeostasis.Purine BiosynthesisThe biosynthesis of purine nucleotides begins with ribose-5-phosphate, a...
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Kinetic Screening of Nuclease Activity using Nucleic Acid Probes
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Smart DNA Hydrogel-Responsive Encoding Enables Portable Nucleic Acid Detection.

Jie Luo, Yu Tang, Hongzhao Yang

  • 1Department of Biological and Environmental Engineering, Cornell University, Ithaca NY14853-5701, United States.

ACS Nano
|February 12, 2026
PubMed
Summary
This summary is machine-generated.

A novel DNA hydrogel platform, Q-RAPID, enables rapid, portable nucleic acid detection. This biosensing device offers high accuracy for identifying pathogens, enhancing diagnostics in diverse healthcare settings.

Keywords:
DNA hydrogelintelligent digital analysisnucleic acid detectionpaper-based microfluidicspoint of care testing

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Fabrication of Electrochemical-DNA Biosensors for the Reagentless Detection of Nucleic Acids, Proteins and Small Molecules
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Area of Science:

  • Biomaterials Science
  • Molecular Diagnostics
  • Biosensing Technology

Background:

  • DNA hydrogels show potential for biosensing but face challenges in portable diagnostics due to slow diffusion and bulkiness.
  • Current methods lack rapid, accurate, and accessible nucleic acid detection for point-of-care applications.

Purpose of the Study:

  • To develop a smart DNA hydrogel-responsive sensing platform, Q-RAPID, for rapid and portable nucleic acid detection.
  • To overcome limitations of existing DNA hydrogel biosensors, improving target delivery, signal amplification, and data output.

Main Methods:

  • Q-RAPID integrates a paper-based scaffold for capillary-driven transport, a hydrogel sensing module for DNA hybridization and strand displacement, and a digital QR code output.
  • The system utilizes a colorimetric reaction triggered by target-specific DNA hybridization for visual signal amplification.
  • Smartphone integration allows for automated classification and wireless reporting of results.

Main Results:

  • Q-RAPID demonstrated high performance in detecting target nucleic acids, achieving 91% sensitivity and 97.3% precision.
  • Testing with a viral pseudovirus model and 100 clinical specimens showed 95% concordance.
  • The platform's design is reconfigurable for detecting various respiratory pathogens.

Conclusions:

  • Q-RAPID offers a promising solution for portable nucleic acid detection, overcoming key limitations of current DNA hydrogel biosensors.
  • The platform's accuracy, speed, and ease of use support its application in diverse healthcare settings, including resource-limited environments.
  • This technology has the potential to broaden the reach of rapid molecular diagnostics.