Related Experiment Video
Updated: Feb 13, 2026

Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV
Published on: March 5, 2022
YTHDF3 at the crossroads of the Epitranscriptome: Structure, networks, and disease roles
Kai Yu1, Jiazhu Sun1, Yuchen Shi1
1Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Cancer Center, Zhejiang University, Hangzhou, Zhejiang, China.
Abstract:
N6-methyladenosine (m6A) is the predominant internal RNA modification that programs RNA splicing, stability, translation, and decay through writer, eraser, and reader proteins. Among readers, YTHDF3 has emerged as a pleiotropic and context-dependent effector. It enhances translation, promotes decay, or stabilizes transcripts-often in concert with YTHDF1/2-and its activities are further tuned by liquid-liquid phase separation and post-translational modifications. Physiologically, YTHDF3 regulates stem-cell fate, neuronal plasticity, and antiviral immunity. In cancer, it exerts dual actions by reinforcing oncogenic and metabolic pathways in many settings, yet restraining tumor growth or immune evasion in others. YTHDF3 also shapes responses to targeted therapy, chemotherapy, and immunotherapy. This review synthesizes the biochemical underpinnings, network positioning, and functional spectrum of YTHDF3, and outlines opportunities for context-specific therapeutic intervention within the epitranscriptomic landscape.
Related Concept Videos
Protein Networks
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Protein Networks
Network Covalent Solids
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
Structure of Lipids
Role of Septins
Cellular Functions of Septins
Recent studies have revealed the multifaceted roles of septins in various cellular processes such as cytokinesis, ciliogenesis, and neurogenesis. Septins act as scaffolds and...
The Role of Culture

