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Association of Growth Hormone Adherence and Growth Outcomes in Paediatric Patients: Results From a Clinical Registry

Tilman Robert Rohrer1, Klaus Hartmann2, Peter Herbert Kann3

  • 1Department of General Pediatrics and Neonatology, Saarland University Medical Center, Homburg, Germany.

Clinical Endocrinology
|February 12, 2026
PubMed

Insights

High adherence to daily growth hormone (GH) therapy significantly improves growth outcomes in children with growth disorders. Maintaining at least 85% adherence leads to better height standard deviation score changes over two years.

Area of Science:

  • Pediatric endocrinology
  • Growth disorders
  • Pharmacological adherence

Background:

  • Daily growth hormone (GH) therapy is crucial for managing pediatric growth disorders.
  • Long-term patient adherence is essential for treatment efficacy.
  • Understanding the impact of adherence on growth outcomes is vital.

Purpose of the Study:

  • To investigate the association between adherence to daily GH therapy and 2-year growth outcomes.
  • To analyze growth improvements in pediatric patients with growth disorders based on adherence levels.
  • To identify optimal adherence thresholds for maximizing growth response.

Main Methods:

  • Retrospective cohort study design.
  • Categorization of patients into low (<85%), high (85%-110%), and >110% adherence groups after 2 years of GH treatment.
  • Analysis of change in height standard deviation score (ΔHSDS) using Spearman's rank correlation and general linear regression.

Main Results:

  • Seventy-four pediatric patients were analyzed.
  • High adherence (≥85%) was significantly positively correlated with ΔHSDS (rs=0.33, p<0.01).
  • High adherence group showed a mean ΔHSDS of 0.87, compared to 0.33 in the low adherence group, with an estimated improvement of 0.44 (p=0.03).

Conclusions:

  • Sustained high adherence (≥85%) to daily GH therapy is associated with clinically meaningful growth improvement over 2 years.
  • Adherence levels directly impact the effectiveness of GH therapy in pediatric patients.
  • Achieving and maintaining high adherence is critical for optimizing growth outcomes in children with growth disorders.
Abstract

Keywords:
adherencecompliancegrowth disordergrowth hormone deficiencygrowth hormonesgrowth outcomes

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