Related Experiment Video
Updated: Feb 13, 2026
06:01
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
15.6K
Intergenerational Conditioning via Intermittent Parental Hypoxia Confers Stroke Resilience in Offspring
Ahmet B Caglayan1,2, Mustafa C Beker2,3, Favour Felix-Ilemhenbhio4
1Division of Hematology and Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor (A.B.C.).
Stroke
|February 12, 2026
Summary
Parental exposure to intermittent hypoxia primes offspring for stroke resilience. This intergenerational conditioning enhances brain protection against ischemic stroke through molecular adaptations.
Area of Science:
- Neuroscience
- Genetics
- Environmental Health
Background:
- Intergenerational disease transmission, influenced by parental exposures beyond genetics, is a key factor in offspring disease susceptibility.
- Environmental conditioning, like intermittent hypoxia, can trigger adaptive brain stress responses.
- The impact of parental intermittent hypoxia on offspring resilience to cerebral ischemia is not well understood.
Purpose of the Study:
- To investigate if parental intermittent hypoxia serves as an intergenerational stimulus for stroke resilience in offspring.
- To explore the molecular mechanisms underlying this inherited neuroprotection against ischemic stroke.
Main Methods:
- Adult mice (parental generation, F0) were exposed to intermittent hypoxia before mating.
- Offspring (first filial generation, F1) from hypoxia-exposed and normoxic parents underwent middle cerebral artery occlusion to model ischemic stroke.
- Infarct volume, brain swelling, and molecular pathways via proteomics were analyzed in both F0 and F1 generations.
Main Results:
- Parental intermittent hypoxia significantly reduced stroke-induced infarct size and brain swelling in F0 mice and this protection was inherited by F1 offspring.
- Biparental exposure offered the most protection, followed by maternal-only and paternal-only exposure, with sex-specific differences observed.
- Proteomic analysis identified key pathways in offspring neuroprotection, including metabolic regulation, immune signaling, and cell survival via PI3K-Akt and EGFR signaling.
Conclusions:
- Parental intermittent hypoxia acts as an intergenerational conditioning stimulus, enhancing offspring resilience to ischemic stroke.
- This inherited neuroprotection is associated with coordinated molecular adaptations in survival and stress response pathways.
- Parental environmental conditioning can significantly influence offspring stroke outcomes, suggesting novel therapeutic strategies.
Keywords:
brain ischemiahypoxiainfarction, middle cerebral arteryischemic preconditioningmice, inbred BALB CproteomicsstrokeMore Related Videos
05:45Delivery of In Vivo Acute Intermittent Hypoxia in Neonatal Rodents to Prime Subventricular Zone-derived Neural Progenitor Cell Cultures
Published on: November 2, 2015
7.7K
05:15Author Spotlight: Accessible M&M-Based Mouse Model for Investigating Binge Eating Disorder - Insights into Eating Behaviors, Anxiety, and Neural Mechanisms
Published on: January 10, 2025
1.8K
Related Concept Videos
00:55Parental Care
12.8K
Many animals exhibit parental care behavior, including feeding, grooming, and protecting young offspring. Parental care is universal in mammals and birds, which often have young that are born relatively helpless. Several species of insects and fish, as well as some amphibians, also care for their young.
12.8K
01:27Parenting Styles
703
Diana Baumrind's four parenting styles — authoritarian, authoritative, neglectful, and permissive — each influence children's socio-emotional development differently.
Authoritarian Parenting
This style is strict and controlling, with little room for open dialogue. Authoritarian parents demand obedience and often enforce rules with minimal warmth. Children raised this way may lack social skills and initiative, usually comparing themselves to others unfavorably.
Authoritative...
Authoritarian Parenting
This style is strict and controlling, with little room for open dialogue. Authoritarian parents demand obedience and often enforce rules with minimal warmth. Children raised this way may lack social skills and initiative, usually comparing themselves to others unfavorably.
Authoritative...
703
01:23Hypoxia
2.2K
Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
2.2K
01:28Relationship with Parents: Attachment
271
Parent-child interactions lay the foundation for how we understand relationships throughout life. These interactions are not uniform across families; instead, they are shaped by a range of environmental, emotional, and behavioral factors unique to each caregiver-child dynamic. Social psychologists study these early relationships to understand how patterns formed in infancy influence social functioning and interpersonal behavior in adulthood.Attachment Theory and Early Relational ModelsJohn...
271
01:23Influence of Parents and Peers on Identity
589
Adolescence is a pivotal period of identity formation, during which individuals begin to answer questions central to their sense of self, such as "Who am I?" and "Who do I hope to become?" Both parents and peers play critical roles in guiding adolescents through this complex developmental phase.
Parental Influence on Identity Development
Parents serve as primary guides and managers in an adolescent's life, offering support instrumental in decision-making and personal growth....
Parental Influence on Identity Development
Parents serve as primary guides and managers in an adolescent's life, offering support instrumental in decision-making and personal growth....
589
01:27Parentral Nutrition: Centeral and Peripheral Parental Nutrition
1.0K
Parenteral Nutrition (PN) delivers essential nutrients directly into the bloodstream, bypassing the digestive system. It is commonly used for individuals with severe digestive disorders or conditions that prevent normal nutrient absorption.
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
1.0K