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Kauro, a graph-based chatbot for high-fidelity information transmission conversations
Charles Hadley King1, Rebekah Barrick1, Miguel Almalvez1
1University of California, Irvine, Institute for Clinical and Translational Science.
Medrxiv : the Preprint Server for Health Sciences
|February 12, 2026
Summary
Kauro is an open-source chatbot for biomedical communication, offering reproducible and auditable informed consent conversations. It uses scripted, deterministic paths for safety and trust in sensitive data exchange.
Area of Science:
- Biomedical informatics
- Clinical research technology
- Artificial intelligence in healthcare
Background:
- Informed consent is critical but complex, labor-intensive, and inconsistent across sites.
- Current digital tools for informed consent lack reproducibility and auditability.
- Generative AI chatbots introduce risks like hallucination and regulatory non-compliance.
Purpose of the Study:
- To introduce Kauro, an open-source, graph-based chatbot for secure and reliable biomedical communication.
- To address the limitations of existing platforms in informed consent processes.
- To enhance reproducibility, auditability, and regulatory oversight in clinical research and care.
Main Methods:
- Developed Kauro, an open-source chatbot utilizing graph-based structures.
- Encoded scripted conversations as version-controlled JavaScript Object Notation (JSON) files.
- Implemented deterministic traversal, comprehensive audit logging, and modular client-server architecture.
Main Results:
- Kauro ensures deterministic conversation paths, enhancing predictability and safety.
- The platform provides complete audit logs, facilitating IRB-verifiable oversight.
- Modular design ensures portability and scalability across different institutions.
Conclusions:
- Kauro offers a scalable solution for safe, precise, and trustworthy biomedical communication.
- It reframes the deployment of AI in healthcare by prioritizing reproducibility and auditability.
- The platform is generalizable to any domain requiring secure and verifiable conversational data.
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