Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

REM Sleep Behavior Disorder01:15

REM Sleep Behavior Disorder

1.8K
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
1.8K
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

462
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
462
Intrinsically Disordered Proteins02:18

Intrinsically Disordered Proteins

19.6K
Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
19.6K
Bone Disorders01:29

Bone Disorders

5.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.5K
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

2.3K
Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
2.3K
Disorders of Leukocytes01:27

Disorders of Leukocytes

2.0K
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hemorrhagic Transformation Mediates Stress Hyperglycemia Effect on Functional Outcome in Minor Ischemic Stroke.

Journal of the American Heart Association·2026
Same author

iSCORE-PD: an isogenic stem cell collection to research Parkinson's disease.

Nature communications·2026
Same author

Oligogenic variants in <i>NEK1</i> and <i>ATXN2</i> in amyotrophic lateral sclerosis: report of two cases and review of the literature.

Amyotrophic lateral sclerosis & frontotemporal degeneration·2026
Same author

Characterization of patients with isolated REM sleep behavior disorder and cerebrospinal fluid α-synuclein negativity.

NPJ Parkinson's disease·2026
Same author

PD GENEration: An International Parkinson's Disease Genetic Research Study.

medRxiv : the preprint server for health sciences·2026
Same author

Prognostic Determinants of Presentation and Outcome in Anti-IgLON5 Disease.

Neurology(R) neuroimmunology & neuroinflammation·2026
Same journal

Comparative Evaluation of Pretrained Large Language Models for Suicide Risk Prediction from Clinical Notes in U.S. Veterans.

medRxiv : the preprint server for health sciences·2026
Same journal

Nocturnal Respiratory Rate and Variability Predict Long-term Mortality in Stable Outpatients with Cardiovascular Disease.

medRxiv : the preprint server for health sciences·2026
Same journal

MOSAIC: Methylation-Oriented Site Analysis and Information Classifier for Robust Epigenomic Classification of Acute Leukemia in Clinical Cohorts with Variable Tumor Purity.

medRxiv : the preprint server for health sciences·2026
Same journal

Risk beliefs, intensive digital information and demand for a new preventative health product in public clinics: Evidence from an experiment in Zimbabwe.

medRxiv : the preprint server for health sciences·2026
Same journal

Development of an automated, imaging-based preoperative screening model for early identification of malnutrition in an abdominal surgery cohort.

medRxiv : the preprint server for health sciences·2026
Same journal

A Pilot Project Leveraging Large Language Models for Automated Screening and Variable Extraction in Observational Studies.

medRxiv : the preprint server for health sciences·2026
See all related articles

Related Experiment Video

Updated: Feb 13, 2026

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

1.6K

Shared Pathogenic Pathways Between REM Sleep Behavior Disorder and Neurodegenerative and Psychiatric Disorders.

Zhao Zhang1,2, Emma N Somerville1,2, Zih-Hua Fang3

  • 1The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montréal, QC, Canada.

Medrxiv : the Preprint Server for Health Sciences
|February 12, 2026
PubMed
Summary
This summary is machine-generated.

This study reveals shared genetic risks between REM Sleep Behavior Disorder (RBD) and neurological/psychiatric conditions. Key pathways like serotonin transport and autophagy link RBD to disorders such as Parkinson's disease.

More Related Videos

Quantitative Analysis of Climbing Defects in a Drosophila Model of Neurodegenerative Disorders
06:30

Quantitative Analysis of Climbing Defects in a Drosophila Model of Neurodegenerative Disorders

Published on: June 13, 2015

19.9K
A Multiple Integrated Social Stress Model for Psychiatric Disorders in Female C57BL/6J Mice
06:15

A Multiple Integrated Social Stress Model for Psychiatric Disorders in Female C57BL/6J Mice

Published on: July 15, 2025

1.3K

Related Experiment Videos

Last Updated: Feb 13, 2026

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

1.6K
Quantitative Analysis of Climbing Defects in a Drosophila Model of Neurodegenerative Disorders
06:30

Quantitative Analysis of Climbing Defects in a Drosophila Model of Neurodegenerative Disorders

Published on: June 13, 2015

19.9K
A Multiple Integrated Social Stress Model for Psychiatric Disorders in Female C57BL/6J Mice
06:15

A Multiple Integrated Social Stress Model for Psychiatric Disorders in Female C57BL/6J Mice

Published on: July 15, 2025

1.3K

Area of Science:

  • Genetics
  • Neuroscience
  • Sleep Medicine

Background:

  • Isolated/idiopathic REM Sleep Behavior Disorder (iRBD) often precedes synucleinopathies.
  • Emerging evidence suggests links between iRBD and other neurological/psychiatric conditions.

Purpose of the Study:

  • To investigate shared genetic risks between iRBD and neurodegenerative/psychiatric disorders using polygenic risk scores (PRS) and rare variant analyses.
  • To identify specific biological pathways and genes implicated in these associations.

Main Methods:

  • Pathway-based PRS were constructed using GWAS data for neurodegenerative and psychiatric traits.
  • Rare variant burden tests were conducted in iRBD cases and controls.
  • Analyses included data from the International RBD Study Group and UK Biobank.

Main Results:

  • Multiple pathways showed shared polygenic risk between iRBD and both neurodegenerative (e.g., Lewy body diseases) and psychiatric disorders (e.g., PTSD).
  • The serotonin transport and chaperone-mediated autophagy pathways exhibited the strongest associations with iRBD.
  • Five genes (GBA1, PLEKHM1, LRP2, P2RX1, HAP1) were associated with iRBD via rare variant analysis, with some replicated in Parkinson's disease and dementia with Lewy bodies.

Conclusions:

  • These findings highlight a shared genetic architecture underlying iRBD, neurodegenerative disorders, and psychiatric traits.
  • The results offer insights for early iRBD identification and understanding its underlying mechanisms.