Related Experiment Video
Updated: Feb 13, 2026
05:41
Metabolic Profile Analysis of Zebrafish Embryos
Published on: January 14, 2013
20.6K
Insomnia-Related Metabolomic Profiles Reflect Antioxidant Deficits and Relate to Cognitive Decline Through a
Cynthia Kusters1, Jose Santos Cabrera2,3,4, Yu Zhang5
1Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA.
Medrxiv : the Preprint Server for Health Sciences
|February 12, 2026
Summary
This study identified specific metabolites linked to insomnia symptoms in U.S. Hispanic/Latino adults. These metabolic changes may also contribute to a higher risk of mild cognitive impairment (MCI) over time.
Area of Science:
- Metabolomics
- Sleep Science
- Neuroscience
Background:
- Insomnia prevalence is high, particularly in Hispanic populations, and is linked to cognitive decline.
- Previous metabolomic studies on sleep disorders have limitations, especially concerning insomnia in Hispanic adults.
- This study addresses gaps by investigating metabolites and cognitive decline in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) cohort.
Purpose of the Study:
- To identify specific serum metabolites associated with insomnia symptoms in U.S. Hispanic/Latino adults.
- To develop and validate metabolite risk scores (MRS) for insomnia symptoms.
- To explore the relationship between identified metabolites, MRS, and cross-phenotypes including cognitive function.
Main Methods:
- Analysis of data from 6,107 participants in the HCHS/SOL study, divided into discovery and replication datasets.
- Examination of 768 serum metabolites and insomnia symptoms using LASSO regression for metabolite risk score (MRS) generation.
- Replication of metabolite associations and evaluation of MRS with sleep, cognitive, and psychological traits.
Main Results:
- Nine metabolites were associated with insomnia symptoms in the discovery phase, with two (hydrocinnamate and indolepropionate) replicated.
- Lower levels of hydrocinnamate and indolepropionate correlated with increased insomnia symptoms.
- The validated WHIIRS MRS was associated with a higher risk of developing mild cognitive impairment (MCI) seven years later (OR: 1.58).
Conclusions:
- The metabolomic profile of insomnia includes diet and gut microbiome metabolites, suggesting shared mechanisms with comorbidities.
- Specific metabolites linked to insomnia may also be associated with an increased risk of cognitive decline.
- Metabolite risk scores show potential for predicting long-term health risks, highlighting the role of metabolomics in sleep and cognitive health research.
Keywords:
Hispanic/Latino adults in the United StatesUntargeted metabolomicsdiscovery and replicationinsomniaMore Related Videos
Related Concept Videos
01:27Insomnia
503
Insomnia is a prevalent sleep disorder characterized by difficulty falling asleep, frequent awakenings during the night, and waking up too early without being able to return to sleep. People with insomnia often experience these disruptions at least three nights a week for at least one month. Chronic insomnia, which lasts for at least three months, can lead to increased anxiety, which in turn can worsen sleep difficulties, creating a cycle of sleeplessness and stress.
Multiple factors contribute...
Multiple factors contribute...
503
01:19Management of Insomnia
683
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
683
01:19Magnetic Declination
487
Magnetic declination is the angle between true north, which aligns with the Earth's rotational axis, and magnetic north, which follows the direction of the Earth's magnetic field. This discrepancy exists because the magnetic poles do not coincide with the geographic poles. The value of magnetic declination depends on the observer's location on Earth and is subject to changes over time due to the dynamic nature of the Earth's magnetic field.The declination is called eastern when magnetic north...
487
02:07Conservation of Declining Populations
13.4K
Conservation of declining population focuses on ways of detecting, diagnosing, and halting a population decline. The approach uses methods to prevent populations from going extinct.
13.4K
01:38Cognitive Dissonance
37.5K
Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
37.5K
00:52What is Metabolism?
132.4K
Overview
132.4K