Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Muscle Stimulation Frequency01:22

Muscle Stimulation Frequency

4.6K
The contraction strength of muscles is regulated by motor neurons, which modulate the frequency of action potentials dispatched to the motor units based on the body's requirements. This process of varying the muscle stimulation frequency allows muscles to contract with a force that is precisely tailored to the needs of the moment, whether lifting a feather or a heavy box.
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...
4.6K
Alternative RNA Splicing02:18

Alternative RNA Splicing

25.3K
Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
25.3K
Alternative RNA Splicing02:18

Alternative RNA Splicing

5.2K
5.2K
Anxiety: Overview01:18

Anxiety: Overview

1.1K
Anxiety is a common mental disorder featuring excessive worry, fear, and apprehension, significantly affecting daily life. People with anxiety disorders experience persistent and intense anxiety, interrupting their everyday functioning.
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
1.1K
Generalized Anxiety Disorder01:30

Generalized Anxiety Disorder

752
Generalized Anxiety Disorder (GAD) is a chronic condition characterized by excessive and uncontrollable worry that persists for at least six months, significantly interfering with daily functioning. Unlike situational anxiety, which arises in response to specific stressors, GAD often occurs without a clear cause. Individuals may experience disproportionate worry about work, health, or relationships. For instance, a person might continuously fear poor health despite normal medical evaluations or...
752
Social Anxiety Disorder01:28

Social Anxiety Disorder

551
Social anxiety disorder, also known as social phobia, is characterized by an intense fear of social situations where one might face humiliation, rejection, embarrassment, or negative evaluation. This disorder leads individuals to avoid activities like casual conversations, public speaking, or seemingly simple tasks such as eating, signing documents, or swimming, in public settings. Its impact extends beyond discomfort, often significantly interfering with daily functioning and quality of life.
551

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Convergent Network Localization of Brain Stimulation Targets for Trait Anxiety.

The American journal of psychiatry·2026
Same author

Bayesian generative modeling reveals a multi-modal hierarchical architecture in the mouse functional connectome.

bioRxiv : the preprint server for biology·2026
Same author

Stable individual differences dominate adult brain volume variation until later life.

Imaging neuroscience (Cambridge, Mass.)·2026
Same author

Reducing state anxiety with alpha-frequency transcranial alternating current stimulation.

Journal of affective disorders·2026
Same author

Cognitive Trajectories After Major Surgery in Older Adults and Factors Associated With Severe Decline.

Journal of the American Geriatrics Society·2026
Same author

Complexity of resting cortical activity predicts neurophysiological responses to theta-burst stimulation but fails to generalize: A rigorous machine-learning approach.

PLoS computational biology·2026

Related Experiment Video

Updated: Feb 13, 2026

The Combination of Transcranial Alternating Current Stimulation and Electroencephalogram
06:14

The Combination of Transcranial Alternating Current Stimulation and Electroencephalogram

Published on: October 10, 2025

550

Reducing state anxiety with alpha-frequency transcranial alternating current stimulation.

Rubén Romero-Marín1, Simon Fankhauser1, Javier Solana-Sánchez1

  • 1Institut Guttmann Institut Universitari de Neurorehabilitació adscrit a la UAB, Badalona, Spain.

Research Square
|February 12, 2026
PubMed
Summary

A single session of alpha-frequency transcranial alternating current stimulation (tACS) modestly reduced anxiety in healthy adults. This neuromodulation technique shows promise for dampening stress-induced anxiety reactivity.

Keywords:
anxietyresiliencestresstACS

More Related Videos

Simultaneous Transcranial Alternating Current Stimulation and Functional Magnetic Resonance Imaging
10:25

Simultaneous Transcranial Alternating Current Stimulation and Functional Magnetic Resonance Imaging

Published on: June 5, 2017

14.7K
Effects of Transcranial Alternating Current Stimulation on the Primary Motor Cortex by Online Combined Approach with Transcranial Magnetic Stimulation
11:11

Effects of Transcranial Alternating Current Stimulation on the Primary Motor Cortex by Online Combined Approach with Transcranial Magnetic Stimulation

Published on: September 23, 2017

9.6K

Related Experiment Videos

Last Updated: Feb 13, 2026

The Combination of Transcranial Alternating Current Stimulation and Electroencephalogram
06:14

The Combination of Transcranial Alternating Current Stimulation and Electroencephalogram

Published on: October 10, 2025

550
Simultaneous Transcranial Alternating Current Stimulation and Functional Magnetic Resonance Imaging
10:25

Simultaneous Transcranial Alternating Current Stimulation and Functional Magnetic Resonance Imaging

Published on: June 5, 2017

14.7K
Effects of Transcranial Alternating Current Stimulation on the Primary Motor Cortex by Online Combined Approach with Transcranial Magnetic Stimulation
11:11

Effects of Transcranial Alternating Current Stimulation on the Primary Motor Cortex by Online Combined Approach with Transcranial Magnetic Stimulation

Published on: September 23, 2017

9.6K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Neuromodulation

Background:

  • Anxiety reactivity to acute stress is a key vulnerability factor across various mental health conditions.
  • Investigating non-invasive brain stimulation techniques like tACS is crucial for understanding and managing anxiety.

Purpose of the Study:

  • To determine if a single session of alpha-frequency transcranial alternating current stimulation (tACS) can reduce state anxiety evoked by acute stress in healthy adults.
  • To assess the impact of tACS on anxiety reactivity by targeting the frontoparietal control network.

Main Methods:

  • A randomized, blinded, sham-controlled study involving 42 healthy adults (mean age 58.9 years).
  • Participants underwent an acute stress task involving a moving-circles paradigm with aversive stimuli before and after active or sham tACS.
  • Active stimulation used 10-Hz alpha-tACS (2.0 mA) delivered to specific scalp locations (F3, P3, Cz, T7).

Main Results:

  • State anxiety (STAI-S) significantly decreased after active tACS but slightly increased after sham stimulation.
  • No significant changes were observed in perceived stress appraisal (SAAS) or resting-state alpha power.
  • Task-related left-frontal alpha power showed trends toward larger increases following active tACS compared to sham.

Conclusions:

  • A single session of alpha-tACS demonstrated a modest yet selective reduction in stress-evoked state anxiety.
  • Oscillatory neuromodulation via alpha-tACS presents a scalable approach for mitigating anxiety reactivity.