Related Experiment Video
Updated: Feb 13, 2026

Roux-en-Y Gastric Bypass Operation in Rats
Published on: June 11, 2012
Prior Roux-en-Y Gastric Bypass Patient With Duodenal Fistula After Perforated Duodenal Ulcer Case Report
Caroline Couch1, Matthew Abourezk1
1Allegheny General Hospital, 320 East North Avenue Suite 592, Pittsburgh, Pennsylvania, USA, wpahs.org.
Abstract:
Perforated duodenal ulcers are a rare occurrence in patients with a history of Roux-en-Y gastric bypass (RNYGB). This case report is of a patient who had two separate presentations of perforated duodenal ulcer despite a history of RNYGB and who progressed to a high-output duodenal-cutaneous fistula after failing the second Graham patch. This highlights the impact ulcer disease can have even in RNYGB patients.
Related Concept Videos
Data Reporting and Recording
Esophageal Perforation-I: Introduction
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
Gastric Motility
Peristaltic Waves and Chyme Formation
Upon food entry, the stomach initiates...
Gastric Emptying
Gastric Phase of Digestion
When food enters the stomach, it stretches the stomach walls and activates stretch receptors. This triggers local reflexes of the enteric nervous system, mediated through the myenteric plexus. These...
Peptic Ulcer Disease II: Pathophysiology
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.

