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Updated: Feb 13, 2026

C. elegans Positive Butanone Learning, Short-term, and Long-term Associative Memory Assays
Published on: March 11, 2011
Loss of SYD-2 leads to decreased short-term memory in Caenorhabditis elegans
Katherine Davies1, Meclina Silva1, Karla Vargas1
1Biology, Sacramento City College, Sacramento, CA, US.
Abstract:
Learning and memory require tight regulation of communication between pre- and postsynaptic responses. SYD-2, the C. elegans ortholog of vertebrate liprin-α, is known for its presynaptic role in active zone maintenance but its role in learning and memory has not been previously investigated. Here, we present findings from 30-minute short-term aversive olfactory memory assay with C. elegans lacking SYD-2 ( ok217 mutants). Wild-type (N2) worms exhibited robust learning and short-term memory for aversion to diacetyl. Despite its role in presynaptic maintenance, we found that the loss of SYD-2 had no effect on aversive learning but decreased short-term associative memory.
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