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Updated: Feb 13, 2026
DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
Published on: February 27, 2014
Video capsule endoscopy in very early onset inflammatory bowel disease: a multicenter retrospective study from the
Wenhui Hu1, Ziqing Ye1, Hailin Wu1
1Department of Gastroenterology, Children's Hospital of Fudan University, Shanghai, China.
Background:
Video capsule endoscopy (VCE) is a noninvasive modality in the assessment among patients with very early onset inflammatory bowel disease (VEOIBD). Little is known about the application of VCE in this rare disorder. The aim of this study is to evaluate the features of patients with VEOIBD undergoing VCE.
Methods:
We retrospectively reviewed 37 VEOIBD patients who underwent VCE from five tertiary centers. Clinical data, including endoscopic findings and treatment were retrieved from medical records. Next generation sequencing was performed to confirm the monogenic defects.
Results:
During a decade, a total of 37 VEOIBD patients were retrospectively included from 5 specialist centers. The total number of VCE procedures performed was 58. The VCE was performed at an average age of 7.8±3.2 years. Twelve patients had undergone follow-up VCE. Next-generation sequencing confirmed the known monogenic inflammatory bowel disease (IBD) in 18 patients. Multiple ulcers, erosions and pseudo-polyps have been identified among patients with TNFAIP3, XIAP and PIK3CD mutations. No adverse effect including capsule retention or endoscopic delivery procedures related adverse effects were reported. Eighteen patients (48.6%) achieved clinical remission.
Conclusions:
This multicenter study showed the features of small bowel lesions among VEOIBD by VCE. Safety of VCE in VEOIBD patients have also been demonstrated.
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