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Related Experiment Video

Updated: Feb 13, 2026

A Method for Characterizing Embryogenesis in Arabidopsis

A Method for Characterizing Embryogenesis in Arabidopsis

Published on: August 4, 2017

An effective method for quantification, visualization, and analysis of 3D cell shape during early embryogenesis.

Zelin Li^1,2, Zhaoke Huang^1,2, Jianfeng Cao^1,2,3

¹Department of Electrical Engineering City University of Hong Kong Hong Kong China.

Quantitative Biology (Beijing, China)

|February 12, 2026

Summary

We developed 3D Cell Shape Quantification (3DCSQ) to analyze complex 3D embryonic cell shapes. This method effectively quantifies cell morphology and tracks differentiation during development.

Keywords:

Caenorhabditis elegans (C. elegans)cell shape quantification eigen features (eigengrid, eigenharmonic & eigenspectrum)lineage analysis morphological reproducibility spherical harmonics (SPHARM)

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Visualizing Neuroblast Cytokinesis During C. elegans Embryogenesis

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Published on: March 12, 2014

Area of Science:

Developmental Biology
Cell Biology
Bioimaging

Background:

Quantifying 3D embryonic cell shape is crucial but challenging.
Traditional methods lack local detail and reconstruction capabilities.
Dynamic cell morphology is key to understanding embryogenesis.

Purpose of the Study:

Introduce 3D Cell Shape Quantification (3DCSQ) for precise 3D cell shape analysis.
Develop analytical feature vectors (eigengrid, eigenharmonic, eigenspectrum).
Systematize cell shape description and monitor cell differentiation.

Main Methods:

Combine spherical grids, spherical harmonics, and principal component analysis.
Transform digitized 3D cell shapes into analytical feature vectors.
Apply 3DCSQ to Caenorhabditis elegans embryos.

Main Results:

3DCSQ effectively recognizes cellular morphological phenotypes and clusters cells.
Identified and quantified reproducible cellular patterns, including skin cell deformations.
Developed an automated cell shape lineaging analysis program.

Conclusions:

3DCSQ offers a systematic approach to cell shape description and evaluation.
The method advances biological imaging by monitoring cell differentiation via shape changes.
This technique provides new insights into developmental processes.