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Updated: Feb 13, 2026

Retinal Pigment Epithelium Transplantation in a Non-human Primate Model for Degenerative Retinal Diseases
Published on: June 14, 2021
Retinal pigment epithelial disruption after retinal detachment repair using perfluorocarbon liquid and gas tamponade:
Viktor Verplaetse1,2, Saskia Helena Margaretha van Romunde1, Michele Manzulli1
1Rotterdam Eye Hospital, Schiedamse Vest 180, 3011BH, Rotterdam, the Netherlands.
Purpose:
To describe two cases of central visual disturbances following uncomplicated pars plana vitrectomy for macula-on retinal detachment.
Observations:
Both patients exhibited a distinctive angled pattern of focal disruptions of the retinal pigment epithelium, observed through fundus autofluorescence and optical coherence tomography. These changes were noted after surgery and remained stable over a 1.5-year follow-up period without any treatment. The pattern of the lesions suggests a mechanical etiology, potentially related to intraocular pressure fluctuations or the use of perfluorocarbon liquid during surgery.
Conclusions And Importance:
This two-case report highlights a distinct post-surgical macular retinal pigment epithelium disruption following vitrectomy for retinal detachment.
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