Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genomics02:02

Genomics

40.9K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
40.9K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

37.3K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
37.3K
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

9.2K
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
9.2K
Transgenic Organisms00:53

Transgenic Organisms

33.6K
Overview
33.6K
Protein Organization01:13

Protein Organization

158.7K
Overview
158.7K
Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes02:16

Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes

17.0K
The present-day mitochondrial and chloroplast genomes have retained some of the characteristics of their ancestral prokaryotes and also have acquired new attributes during their evolution within eukaryotic cells. Like prokaryotic genomes, mitochondrial and chloroplast genomes neither bind with histone-like proteins nor show complex packaging into chromosome-like structures, as observed in eukaryotes. Unlike mitotic cell divisions observed in eukaryotic cells, mitochondria and chloroplasts...
17.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparison of frequency-resolved optical polarization gating induced by molecular alignment and Kerr effects.

Optics letters·2012
Same author

Direct transformation of simple enals to 3,4-disubstituted benzaldehydes under mild reaction conditions via an organocatalytic regio- and chemoselective dimerization cascade.

Chemistry (Weinheim an der Bergstrasse, Germany)·2012
Same author

[Digital anatomy of the perforator flap in the thigh].

Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery·2012
Same author

[Value of methylation-specific mutiplex ligation-dependent probe in the diagnosis of Prader-Willi syndrome].

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics·2012
Same author

Elevated local TGF-β1 level predisposes a closed bone fracture to tuberculosis infection.

Medical hypotheses·2012
Same author

Modulation of P-glycoprotein expression by triptolide in adriamycin-resistant K562/A02 cells.

Oncology letters·2012

Related Experiment Video

Updated: Feb 13, 2026

Revealing the Cytoskeletal Organization of Invasive Cancer Cells in 3D
11:09

Revealing the Cytoskeletal Organization of Invasive Cancer Cells in 3D

Published on: October 26, 2013

16.2K

3D genomic organization in cancers.

Junting Wang1, Huan Tao1, Hao Li1

  • 1Institute of Health Service and Transfusion Medicine Beijing 100850 China.

Quantitative Biology (Beijing, China)
|February 12, 2026
PubMed
Summary

Altered three-dimensional (3D) chromatin structures are implicated in cancer development. Advanced bioinformatics, including machine learning, offers new insights into the 3D cancer genome for diagnosis and treatment.

Keywords:
cancerchromatin compartmentloopthe three‐dimensional (3D) genometopologically associated domain (TAD)

More Related Videos

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms
09:51

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms

Published on: May 25, 2018

35.9K
Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization
13:55

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization

Published on: February 3, 2013

19.0K

Related Experiment Videos

Last Updated: Feb 13, 2026

Revealing the Cytoskeletal Organization of Invasive Cancer Cells in 3D
11:09

Revealing the Cytoskeletal Organization of Invasive Cancer Cells in 3D

Published on: October 26, 2013

16.2K
Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms
09:51

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms

Published on: May 25, 2018

35.9K
Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization
13:55

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization

Published on: February 3, 2013

19.0K

Area of Science:

  • Genomics
  • Cancer Biology
  • Bioinformatics

Background:

  • Hierarchical three-dimensional (3D) chromatin architecture is crucial for biological processes like cell differentiation and transcriptional regulation.
  • Aberrant 3D chromatin structures are linked to human diseases, including cancer, but the mechanisms are not fully understood.

Purpose of the Study:

  • To explore the role of 3D chromatin structures in cancer development.
  • To highlight the potential of bioinformatics in studying the 3D cancer genome.

Main Methods:

  • Review of current literature on 3D chromatin structure and cancer genomics.
  • Application of bioinformatics techniques, including machine learning and deep learning, for 3D cancer genome analysis.

Main Results:

  • Specific 3D chromatin features (compartment A/B, topologically associated domains, enhancer-promoter interactions) are critical in cancer progression, metastasis, and drug resistance.
  • Bioinformatics approaches, particularly machine learning, show significant promise for investigating the 3D cancer genome.

Conclusions:

  • Advances in 3D cancer genome research enhance understanding of tumorigenesis mechanisms.
  • This knowledge can lead to improved cancer diagnosis and personalized treatment strategies.