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Extracellular vesicle-mediated microRNA signaling: expanding insights into intercellular communication and disease
Syeda Tayyaba Batool1, Umair Ali2, Muhammad Ijaz Khan2
1Department of Medicine, Azad Jammu and Kashmir Medical College (Affiliated with UHS), Muzaffrabad, Pakistan.
None:
Extracellular vesicles (EVs), particularly exosomes, have emerged as key mediators of intercellular communication by transporting microRNAs (miRNAs). Recent studies indicate that EV-associated miRNAs regulate gene expression across diverse physiological and pathological processes, including cancer metastasis, neuroinflammation, kidney injury, and cardiovascular disease. Understanding the selective packaging, trafficking, and functional consequences of EV-miRNA transfer may enable the development of biomarkers and targeted therapies based on vesicle-mediated signaling.
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