Long-term safety and effectiveness of hybrid coronary revascularization compared to conventional revascularization

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Singam Shashank1, Rashmikaa Netyam1, Chiranjeevee R Saravanan2

  • 1General Medicine, Hampshire Hospitals, NHS Foundation Trust, Basingstoke, UK.

Annals of Medicine and Surgery (2012)
|February 12, 2026
PubMed

Insights

Hybrid coronary revascularization (HCR) offers similar safety and effectiveness to traditional coronary artery bypass grafting (CABG) for multivessel coronary artery disease. This emerging treatment shows comparable outcomes at 30 days and 1 year.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Cardiac Surgery

Background:

  • Hybrid coronary revascularization (HCR) combines percutaneous coronary intervention and coronary artery bypass grafting (CABG).
  • It is an emerging treatment for multivessel coronary artery disease (MVCAD).
  • HCR may address issues like saphenous vein graft failure associated with traditional CABG.

Purpose of the Study:

  • To systematically evaluate the safety and effectiveness of HCR compared to CABG in MVCAD patients.
  • To compare key clinical outcomes between HCR and CABG at 30 days and 1 year post-procedure.

Main Methods:

  • A systematic literature search was conducted across PubMed, Scopus, Web of Science, and Embase until September 2024.
  • Included were four randomized controlled trials (RCTs) with 382 participants, analyzed using a random-effects model.
  • Risk of bias was assessed using the ROB2 tool, and data were analyzed with RevMan 5.4.

Main Results:

  • At 30 days, no significant differences were found between HCR and CABG for all-cause death, stroke, myocardial infarction, or blood transfusion (all P > 0.14).
  • At 1-year follow-up, pooled analyses revealed no significant differences in all-cause death or myocardial infarction (all P > 0.56).
  • All outcome comparisons demonstrated zero heterogeneity (I² = 0%).

Conclusions:

  • Hybrid coronary revascularization (HCR) demonstrates comparable safety and effectiveness to coronary artery bypass grafting (CABG) for multivessel coronary artery disease (MVCAD).
  • Key clinical outcomes are similar between HCR and CABG at both 30-day and 1-year follow-up points.
  • Further research with larger sample sizes and longer follow-up periods is recommended to solidify these findings.
Abstract

Keywords:
coronary artery bypasshybrid proceduresmultivessel coronary diseasemyocardial revascularizationpercutaneous coronary intervention

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