Related Experiment Video
Updated: Feb 13, 2026

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Extra-anatomic bypass for aortic obstruction below the renal arteries with bilateral iliac artery occlusion
Mohammed Mayo1, Allaith Souweid1, Sana Debajawish1
1Faculty of Medicine, University of Aleppo, Aleppo, Syria.
Insights
Axillofemoral bypass provides a viable limb salvage option for patients with complex aortoiliac occlusive disease (AIOD) and high surgical risks. This extra-anatomic bypass effectively restored circulation and relieved symptoms in a challenging case.
Area of Science:
- Vascular Surgery
- Atherosclerosis Research
- Medical Case Studies
Background:
- Aortoiliac occlusive disease (AIOD), or Leriche syndrome, involves atherosclerotic narrowing of the aorta and iliac arteries.
- Standard treatments like aortobifemoral bypass may be unsuitable for patients with complex anatomy or comorbidities.
- Axillofemoral bypass serves as an extra-anatomic alternative for limb salvage in high-risk individuals.
Background:
Aortoiliac occlusive disease (AIOD), or Leriche syndrome, results from progressive atherosclerotic narrowing of the infrarenal aorta and iliac arteries, causing claudication, diminished femoral pulses, and erectile dysfunction in men. While aortobifemoral bypass or endovascular repair are standard treatments, these may be unsuitable for patients with hostile abdominal anatomy or major comorbidities. In such cases, axillofemoral bypass offers an extra-anatomic alternative for limb salvage.
Case Presentation:
A 47-year-old male, heavy smoker with a prior aortofemoral bypass and chronic limb-threatening ischemia, presented with bilateral rest pain and right leg necrosis. Imaging revealed complete occlusion of the infrarenal aorta and both iliac arteries. Given hostile abdominal anatomy, reduced cardiac function (LVEF 40%), and prior surgeries, a staged axillobifemoral bypass was performed using a 7-mm ring-reinforced PTFE graft, along with an above-knee amputation of the necrotic limb. Postoperatively, femoral and pedal pulses were palpable, and duplex confirmed graft patency. At 6 months, the patient remained asymptomatic with sustained graft function.
Discussion And Conclusion:
Axillofemoral bypass, though less durable than anatomical bypass, is an effective option for high-risk AIOD patients when conventional revascularization is contraindicated. This case highlights its role in achieving limb salvage and symptom relief in complex vascular disease.
Related Concept Videos
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
Arteries of Lower Limbs
Arteries and Arterioles
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...

