Related Experiment Video
Updated: Feb 13, 2026

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
Published on: November 30, 2016
The Association Between Irritable Bowel Syndrome and Generalized Anxiety Disorder and Influencing Factors: A
Weili Yang1, Yongxi Wang2, Shasha Wang2
1School of Public Health, Department of Applied Psychology Shaanxi University of Chinese Medicine Xianyang Shaanxi China.
None:
Previous studies showed that irritable bowel syndrome (IBS) and generalized anxiety disorder (GAD) share a common pathogenic mechanism. However, research on links between immune cells, plasma metabolites, inflammatory factors, and gut microbiota and these diseases remains limited. This study aimed to probe causal relationships between these factors and IBS/GAD using Mendelian randomization (MR) analysis. Among factors associated with IBS, 25 gut microbial taxa, 103 plasma metabolites, 7 inflammatory factors, and 42 immune cell characteristics had causal relationships with IBS. Among factors associated with GAD, 35 gut microbial taxa, 72 plasma metabolites, 6 inflammatory factors, and 43 immune cell characteristics had causal links to GAD. IBS was appointed as a risk factor for GAD [odds ratio (OR) = 1.328; p < 0.001]. Mediation analysis showed that IBS acted as a mediator, modulating the effects of 1 immune cell, 1 gut microbiota, and 2 plasma metabolites on GAD. IBS attenuated the protective effects of "Bilophila" on GAD onset (13.30%). This study respectively revealed the potential causal roles of multiple factors in IBS and GAD, as well as the causal relationship between IBS and GAD. Additionally, the mediating role of IBS was unveiled, delivering fresh perspectives on the pathogenesis of IBS and GAD.
Related Concept Videos
Generalized Anxiety Disorder
Irritable Bowel Syndrome I: Introduction
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome III: Medical and Nursing Management
Social Anxiety Disorder
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

