Related Experiment Video

Updated: Feb 13, 2026

Isolation and Characterization of Primary Rat Valve Interstitial Cells: A New Model to Study Aortic Valve Calcification
08:55

Isolation and Characterization of Primary Rat Valve Interstitial Cells: A New Model to Study Aortic Valve Calcification

Published on: November 20, 2017

10.3K

Shared genetic links between cardiometabolic diseases and aortic valve calcification

KaiJian Zhang1, Yi Zhang2, JingHan Chu3

  • 1Department of Cardiology, Ma'anshan People's Hospital, Wannan Medical College, Ma'anshan, 243099 Anhui China.

Indian Journal of Thoracic and Cardiovascular Surgery
|February 12, 2026
PubMed

Insights

Cardiometabolic disorders are linked to calcific aortic valve stenosis (CAVS) through shared genetic factors. This study confirms a causal association, offering insights into disease mechanisms and potential therapies.

Area of Science:

  • Cardiovascular Genetics
  • Metabolic Diseases
  • Valvular Heart Disease

Background:

  • Cardiometabolic disorders are increasingly recognized as risk factors for calcific aortic valve stenosis (CAVS).
  • The precise biological mechanisms linking these conditions remain incompletely understood.
  • Understanding this relationship is crucial for developing effective prevention and treatment strategies.

Purpose of the Study:

  • To investigate the causal association between cardiometabolic diseases and CAVS.
  • To identify shared genetic underpinnings between these conditions.
  • To leverage genetic correlation and Mendelian randomization analyses for robust evidence.

Main Methods:

  • Utilized genome-wide association study (GWAS) data from the FinnGen consortium for seven cardiometabolic disorders and CAVS.
  • Employed linkage disequilibrium score regression (LDSC) and high-definition likelihood (HDL) for genetic correlation analysis.
  • Performed bidirectional two-sample Mendelian randomization (MR) analysis, primarily using inverse-variance weighted (IVW) regression, with sensitivity analyses.

Main Results:

  • Identified 12 shared genes implicated in both cardiometabolic disorders and CAVS.
  • Functional enrichment analysis highlighted the involvement of these genes in cholesterol homeostasis, vascular remodeling, smooth muscle proliferation, and lipid accumulation.
  • Mendelian randomization analysis provided evidence supporting a causal relationship between cardiometabolic disorders and CAVS.

Conclusions:

  • Demonstrated a significant genetic overlap between cardiometabolic disorders and CAVS.
  • These findings elucidate potential mechanisms driving the co-occurrence of these conditions.
  • The results have implications for future therapeutic interventions targeting shared pathways.
Abstract

Keywords:
Calcific aortic valve stenosisCardiometabolic diseaseGenetic correlationMendelian randomization

More Related Videos

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro05:47

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro

Published on: May 10, 2021

4.7K
Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat04:30

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat

Published on: February 4, 2021

3.7K

Related Concept Videos

Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
9.7K
What is Genetic Engineering?00:49

What is Genetic Engineering?

Overview
80.4K
Heart Valves01:16

Heart Valves

The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
12.3K
X-linked Traits01:19

X-linked Traits

In most mammalian species, females have two X sex chromosomes and males have an X and Y. As a result, mutations on the X chromosome in females may be masked by the presence of a normal allele on the second X. In contrast, a mutation on the X chromosome in males more often causes observable biological defects, as there is no normal X to compensate. Trait variations arising from mutations on the X chromosome are called “X-linked”.
58.9K
Genetics of Speciation02:16

Genetics of Speciation

Speciation is the evolutionary process resulting in the formation of new, distinct species—groups of reproductively isolated populations.
21.9K
What is Population Genetics?01:25

What is Population Genetics?

A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
65.0K