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Published on: July 25, 2017
Harnessing gut microbiota for longevity: Insights into mechanisms and genetic manipulation
Peng Shi1, Simin Xu2, Ziling Yang1
1Jiangsu Engineering Research Center for Precision Diagnosis and Treatment of Polygenic Critical Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics Xuzhou Medical University Xuzhou China.
Abstract:
The gut microbiota is pivotal in maintaining health, with most microorganisms being beneficial, except for a few pathogens. Emerging evidence suggests a link between the gut microbiome and aging, hinting at its potential role in longevity. However, understanding the relationship is challenging due to the microbiota's complexity. This perspective summarizes the mechanisms by which gut microbes regulate host lifespan and explores genetic manipulation strategies to promote healthy aging in the elderly.
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