Enteric nervous system in microbiota-associated gut inflammation.

Area of Science:

• Neurogastroenterology
• Microbiome research
• Immunology

Background:

• The enteric nervous system (ENS) autonomously controls gut functions and interacts with immune cells.
• The gut microbiota and its metabolites impact mucosal integrity and inflammation.
• The ENS is constantly exposed to signals from the gut microenvironment.

Purpose of the Study:

• To review the intricate interplay between the ENS and gut microbiota.
• To examine their roles in the pathogenesis of intestinal inflammation.

Main Methods:

• Literature review of studies on ENS-microbiota interactions.
• Analysis of mechanisms linking microbiota, ENS, and immune responses.

Main Results:

• Gut microbiota influences ENS development, repair, and function.
• Microbiota-derived signals modulate immune responses within the gut.
• Dysbiosis can contribute to ENS dysfunction and inflammatory conditions.

Conclusions:

• The ENS and gut microbiota are critical components in maintaining gut homeostasis.
• Understanding their interplay is key to developing therapies for intestinal inflammation.