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KRTCAP2 accelerates malignant progression through modulating tumor cell function and M2 macrophage infiltration in
Chunmei Zhao1, Yijie Sheng2,3, Jianfei Huang4
1Department of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China.
Frontiers in Immunology
|February 12, 2026
Summary
Keratinocyte-associated protein 2 (KRTCAP2) promotes glioma growth and immune evasion. Targeting KRTCAP2 may improve patient prognosis and response to therapies like temozolomide.
Area of Science:
- Oncology
- Molecular Biology
- Immunology
Background:
- Aberrant protein glycosylation influences tumor growth and immune responses.
- Keratinocyte-associated protein 2 (KRTCAP2) is involved in N-glycosylation, but its role in glioma is unclear.
Purpose of the Study:
- To investigate the functions of KRTCAP2 in glioma tumorigenesis and immune evasion.
- To assess KRTCAP2 as a prognostic biomarker for glioma.
Main Methods:
- Bioinformatics analysis of KRTCAP2 expression and immune microenvironment.
- Multiplex immunohistochemistry for protein expression and immune cell infiltration.
- In vitro assays to determine KRTCAP2 function in glioma cells.
Main Results:
- KRTCAP2 was upregulated in glioma and associated with poor prognosis and increased tumor-associated macrophages.
- KRTCAP2 depletion inhibited glioma cell proliferation, migration, and invasion.
- KRTCAP2 expression correlated with chemoresistance, and its inhibition sensitized cells to temozolomide.
Conclusions:
- KRTCAP2 is a novel prognostic biomarker in glioma.
- KRTCAP2 promotes an immunosuppressive tumor microenvironment and is a potential therapeutic target.
- KRTCAP2 may predict immunotherapy response.
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