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The association between cardiovascular health, measured using Life's Essential 8, and obstructive sleep apnea: a

Hong Zhai1, Zhouyan Lin1, Minshu Ao1

  • 1Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Naval Medical University Shanghai, China.

American Journal of Translational Research
|February 12, 2026
PubMed

Insights

Maintaining good cardiovascular health (CVH) significantly lowers the risk of developing Obstructive Sleep Apnea (OSA). Better CVH, measured by the Life's Essential 8 (LE8) score, is strongly associated with reduced OSA prevalence.

Area of Science:

  • Cardiology
  • Pulmonology
  • Public Health

Background:

  • Cardiovascular health (CVH), assessed via the Life's Essential 8 (LE8) construct, impacts numerous health outcomes.
  • Obstructive Sleep Apnea (OSA) is a growing public health concern with known links to CVH, yet this relationship requires deeper investigation.

Purpose of the Study:

  • To investigate the association between CVH, quantified by the LE8 score, and the prevalence of OSA.
  • To explore the causal relationship between CVH and OSA using Mendelian randomization.

Main Methods:

  • Utilized data from 9,350 adults (aged 20-79) from the National Health and Nutrition Examination Survey (NHANES) (2005-2008, 2015-2018).
  • Employed logistic regression to analyze the association between LE8 scores and OSA.
  • Applied two-sample Mendelian randomization with the inverse-variance weight (IVW) method to assess causality.

Main Results:

  • Individuals with better CVH (higher LE8 scores) exhibited significantly lower odds of OSA (OR: 0.23, 95% CI: 0.18-0.30).
  • A dose-dependent relationship was observed, where higher LE8 scores correlated with decreased OSA risk.
  • Genetically determined higher BMI, smoking, and lower physical activity were associated with increased OSA risk.

Conclusions:

  • Maintaining optimal cardiovascular health, as indicated by the LE8 score, is crucial for reducing the risk of Obstructive Sleep Apnea.
  • These findings underscore the importance of public health initiatives promoting CVH to mitigate OSA prevalence.
Abstract

Keywords:
Life’s Essential 8Mendelian randomizationNHANESObstructive sleep apneacardiovascular health

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