TBCancer: A database for exploring characteristics and functions of tissue-biased genes in cancer
Zhuobin Lin1, Kunhua Hu1, Hongyan Sun2
1Guangdong Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat‑sen University Sun Yat-sen University Guangzhou China.
Abstract:
This study defined 10,921 tissue-biased genes across 54 normal tissues and 41 cancer types. Tumor-associated tissue-biased genes exhibit downregulation, mutations, and epigenetic modifications, correlating with poor clinical outcomes. Their inactivation promotes tumorigenesis by enhancing stemness and immune evasion, highlighting their value as prognostic biomarkers and therapeutic targets. To facilitate research, we developed a database integrating multi-omics data on these genes for mechanistic and therapeutic exploration.
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