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Updated: Feb 13, 2026

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MOMMY study profile: An integrative early-life multi-omics cohort in China.

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|February 12, 2026
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Summary

The MOMMY cohort study tracks 20,000 Chinese families to understand how the mother-infant microbiome and environment impact child health. This research provides crucial insights into early-life development and disease risk.

Keywords:
MOMMYearly lifelongitudinal cohortmicrobiome

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Area of Science:

  • Microbiome research
  • Developmental biology
  • Environmental health

Background:

  • Large birth cohorts are vital for studying early-life health, but are lacking in Asian populations.
  • Understanding the gut microbiome's role in early development is critical.

Purpose of the Study:

  • To establish the MOMMY cohort, a large prospective birth cohort in China.
  • To investigate maternal-paternal-infant microbiota transmission and its impact on child health.
  • To fill a gap in global microbiome research concerning Asian populations.

Main Methods:

  • Recruiting 20,000 families across diverse Chinese regions.
  • Collecting longitudinal biospecimens (stool, breast milk, blood) from mothers, fathers, and infants.
  • Gathering extensive data on environmental exposures, diet, and health outcomes.
  • Integrating multi-omics data (metagenomic, metabolomic, immunologic, epigenetic).

Main Results:

  • Established the MOMMY cohort, a unique resource for studying early-life health.
  • Systematically collected longitudinal biospecimens and comprehensive health data.
  • Initiated the integration of multi-omics data for in-depth analysis.

Conclusions:

  • The MOMMY cohort will elucidate how early-life microbial and molecular trajectories influence child development and disease risk.
  • This study addresses a critical gap in understanding the microbiome's role in child health within the Chinese population.
  • The cohort provides a unique resource for future research on early-life health and disease prevention.