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    A novel injectable cell therapy platform, INSITE (Injected Self-assembled Image-guided Tissue Ensembles), enables minimally invasive liver cell delivery. This approach improves cell engraftment and function for potential end-stage liver disease treatments.

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    Area of Science:

    • Regenerative Medicine
    • Biomaterials Science
    • Hepatology

    Background:

    • Liver transplantation is limited by donor scarcity and access issues.
    • Current cell therapies face challenges with engraftment, localization, and delivery methods.

    Purpose of the Study:

    • To develop a minimally invasive, image-guided cell delivery platform for liver cell therapy.
    • To create an injectable, self-assembling scaffold that supports cell function and vascularization.

    Main Methods:

    • Developed INSITE (Injected Self-assembled Image-guided Tissue Ensembles), an injectable platform of hepatocytes and hydrogel microspheres.
    • Utilized ultrasound-guided injection for precise delivery and in situ scaffold assembly.
    • Assessed graft localization, vascular integration, cell function, and scaffold remodeling in vivo.

    Main Results:

    • INSITE enabled precise, image-guided delivery and in situ scaffold formation.
    • Achieved persistent graft visibility, vascular integration, and long-term hepatocyte function.
    • Demonstrated control over scaffold properties to enhance graft function and vascular recruitment.

    Conclusions:

    • INSITE provides a clinically compatible strategy for minimally invasive cell therapies.
    • This platform addresses key challenges in cell therapy delivery and engraftment.
    • Offers a promising approach for treating end-stage liver disease and other conditions.